Статьи журнала - Cardiometry
Все статьи: 527
Статья научная
The aim is to study the content of prekallikrein, kallikreins 1 and 14 (KLK-1 and KLK-14) in mice under the conditions of activation and inhibition of the B16/F10 inoculated melanoma growth. Materials and methods We produced a model of chronic neurogenic pain (CNP, bilateral ligation of sciatic nerves) and a model of the B16/F10 melanoma growth against the background of CNP using female/male mice of the C57BL/6 line (with normal genome, n=75) and the C57BL/6-Plautm1.1bugthisplaughfdhu/GFDhu line (with urokinase knockout (uPA), n=46). The ELISA method was used to determine the content of prekallikrein, KLK1 and KLK14 in the tumor and skin after 3 weeks of carcinogenesis against the background of CNP. Results The initially high content of prekallikrein, KLK-1 and KLK-14 in the skin of intact knockout mice was found. When inhibiting the growth and metastasis of melanoma in the skin of the knockout females, noted was a further increase in the initially high level of prekallikrein and KLK1, and in the tumor in the knockout mice of both genders recorded was a lower content of all the studied enzymes. When activating the growth of melanoma in the state of CNP in the skin of C57BL/6 mice, the level of KLK1 (female) decreased and the concentration of KLK14 (female and male) increased; in the knockout mice the content of prekallikrein and KLK14 decreased, and KLK1 changed multidirectionally. The tumor demonstrated a lower prekallikrein level in all C57BL/6mice and multidirectional changes in KLK1 and KLK14 in females and males. The tumor in the knockout animals showed a lower content of all the studied enzymes, especially pronounced for KLK14. Conclusion The content of prekallikrein, KLK1 and KLK14 varies under activating and inhibiting the growth of melanoma, the changes are of the gender-specific type. It is probable that the functions of the studied enzymes in the skin change not only in case of CNP, but also in case of urokinase deficiency. The tumor itself adapts the performance of the kallikrein-kinin system depending on the metabolic features of the tumor-bearing organism.
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Inhalation health risk assessment of some of heavy metals for kerosene samples in Iraq market
Статья научная
In this study, five heavy metals (Zn, Fe, Pb, Cu, and Cd) concentrations were measured in samples of kerosene (locally only) that collected from different of warehouses oils in Iraq. The measurements have been done using Atomic Absorption Spectrophotometer. Non-cancer risks such as the chronic daily inhalation intake (CDIinh), a Hazard Quotient (HQ), and Haz-ard Index (HI) as well as Cancer Risks (CR) due to inhalation of heavy metals in the kerosene samples were calculated. The results show that, the average values of concentrations in unit ppm (mg/kg) belonging to Zn, Fe, Pb, Cu, and Cd in kerosene samples were 8.14±1.74, 0.127±0.025, 0.017±0.007, 0.15±0.064, and 0.360±0.022, respectively. While, the average value of Haz-ard Index (HI) due to all heave metals in the present work was 0.721± 0.16. Also, the average value of Total Cancer Risk (TCR) due to Cd and Pb were 1.12E-03±4.4E-04. When comparing the results of inhalation health risk, the present work with Worldwide average, we found that the most samples of kerosene samples are safe for using.
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Статья
At the present stage, the problems of preventive oncology are becoming more and more important, especially, at the stages of blastomogenesis, recurrence and metastasizing of tumors. Preventive measures can also be aimed at regulating the stress syndrome, improving the efficiency and safety of chemoradiotherapy, and improving the quality of life and rehabilitation processes for cancer patients. Promising in this aspect are approaches, which take into account the unique capabilities of natural antitumor geroprotectors: phytoadaptogens (PhA)
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Innovative technologies for the treatment of cervical intraepithelial neoplasia of the cervix
Статья научная
The problem of pathological conditions of the cervix attracts great attention of doctors of many specialties, which is due to the ambiguity of the prognosis of this pathology. The detection of gynecological pathology, including cervical pathology, depends on the use of screening diagnostic methods, improvement of preventive and therapeutic measures carried out in an outpatient setting. In modern medical practice diseases of the cervix uteri occupy a leading position due to the high the frequency of their occurrence, frequent transformation into precancerous conditions, which in turn can be the cause of cervical cancer. Today, both in world practice and in Uzbekistan in the structure of oncological diseases of the genital organs in women cervical cancer is the second most common disease, causing high mortality of patients.
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Inseparable relationship between intellectual services and high-tech medical equipment
Статья обзорная
The social problems in any country, related to public health and demography, induce developments and production of diagnostic and therapeutic medical equipment. Such equipment belongs to high-tech products and requires to be accompanied by intellectual services for a successful promotion of medical products on the market under modern competitive conditions. The authors hereof substantiate the need to develop intellectual services for companies manufacturing high-tech medical equipment. The article treats the concept of intellectual services, the peculiarities of the intellectual services market in Russia, the special features of high-tech medical products promotion, as well as instruments for promoting the intellectual services by high-tech medical equipment manufacturers.
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Статья научная
Diabetes mellitus is an additional risk factor for the development of heart diseases, cardiovascular dysfunction and malignant tumors. The aim of the study was to analyze levels of IGF and IGFBP in heart samples of animals with diabetes mellitus and/ or growing Guerin’s carcinoma. The study included white outbred rats of both genders weighing 180-220 g. The rats of each gender were divided into groups of 8 animals: the intact group; test groups 1 (with diabetes) and 2 (with transplanted Guerin’s carcinoma); the main group (transplanted Guerin’s carcinoma growing in the presence of diabetes mellitus). Levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-2 were measured by ELISA (Mediagnost, Germany) in heart homogenates in animals of all groups
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Intelligent digitalization of cardiovascular risks
Статья научная
The aim of the study was to develop a mathematical model of the risks of the cardiovascular system based on the selected factors affecting cardiovascular diseases (CVD) and to test the developed mathematical model on a sample of clinical examples. CVD risk factors was grouped by types: biological indicators (anthropometric, biochemical, morphological, physiological), disease indicators, social indicators. An assessment of the degree of risk for each of the indicators was carried out by calculating the degree of risk using the membership formula, then evaluating the hazard class (according to the degree of risk) using a logical-linguistic model and a training algorithm for the neural fuzzy classifier of the network. The correctness of the risk determination by the developed model was confirmed by the analyzed 60 verified cases of acute cerebrovascular accident (18 men and 42 women). The analysis of the test results of the constructed neuro-fuzzy classifier allows us to conclude that it works satisfactorily even when using incomplete information, which makes it possible to use it for prompt decision-making. The results of testing on clinical examples, with an acceptable level of significance of a type I error of 0.05, showed that the risk was determined correctly. The factors influencing the risk of CVD are identified and designated as the corresponding linguistic variables. A logical-linguistic model was built, from which a transition was made to a hybrid neuro-fuzzy classifier, which allows assessing the influence of the identified factors on the level of risk of CVD. As a result of approbation of the model of intellectual digitalization of risks of the cardiovascular system on real clinical examples, it was confirmed that the risk was determined correctly, which means that it is possible to assert about the prospects for introducing this model into clinical practice and guaranteeing medical specialist more accurate diagnosis and optimization of their activities.
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Interaction between the mother and the fetus in the aspect of immunology
Статья научная
The article deals with the interaction between the mother and the fetus in the aspect of immunology. The immunological problems which the maternal immune system may encounter in pregnancy and their potential negative effects on the fetal health are also of interest to us. Therefore, it is necessary to consider the features of the interaction between the fetus and the mother, which will allow assessing the prospects for future research in the field of the interaction between the maternal and fetal immune systems for more effective prevention and treatment of immunological problems in pregnancy.
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Interdisciplinary educational approaches in healthcare organizations
Статья научная
Background: Healthcare professionals’ perception of Interdisciplinary Education is an essential factor that affects their acceptance of this approach to education. From the literature related to patient safety, it has been identified widely that healthcare team communication and performance are critical to providing safe care to the patient. Poor organization and team dynamics among healthcare professionals appear to impact the safety and quality of patient care. The lack of Interdisciplinary Education in healthcare institutions in the Kingdom of Saudi Arabia negatively impacts the work dynamics of the healthcare team. Results: The study results showed that the majority of health care workers showed a high awareness level for IPE. Therefore, female nurses who have been working in special units and have experience of more than five years are perceived more than other specialties. Also, health workers in special units showed a higher percentage than in the general wards, and females were ready more than males. Only one item helped to determine the differences in perception which is the “perceived need for cooperation”. Conclusions: IPC should be initiated by universities than by health organizations starting at the level of leaders of medicine, nursing, and other disciplines who should be aware of the importance of IPC that would benefit patients as well as health institutions. Leaders must take IPC cooperation seriously by putting it into consideration in the vision of departments and thus starting to establish small-cooperated teams, which include various specialties.
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Статья
Degenerative brain diseases (DBD) and other cognitive dysfunctions may appear due to the depletion of adaptive reserves as a result of aging, stress, depression, and other pathological processes (inflammation, malignant neoplasms). The depletion of the adaptive reserves leads to disordering accurate, appropriate signaling in the brain, between the brain and the body, as well as disorders at the levels of the organs, cells and molecules. The body's adaptive reserves ultimately determine the tolerability or the resistance to various degrees of hypoxia, which accompanies stress, trauma, depression, inflammation, and aging. Oxygen is the most important and fastest regulator of metabolism. The fundamental concept is as follows: optimal health is activated and stimulated by intermittent stimulation, i.e. moderate functional loads [1, 2]. We offer practical programs, which combine two non-pharmacological natural methods of activation therapy, training aimed at improving the adaptive reserve of the human body: intermittent fasting treatment (IFT) and interval hypoxic training (IHT).
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Intermittent hypoxia as a method of training and treatment
Отчет
For centuries, the scientific community has been aware of the cellular importance of oxygen, which converts food into energy and is transported to the tissues by red blood cells. It is known that oxygen gives life and life energy and takes them away.Training with intermittent hypoxia, interval hypoxic training (IHT) is one of the most promising additional non-drug therapies that activate the natural defences of the human body and provide the body with a high degree of adaptation.
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Intermittent hypoxic training as an effective method of activation therapy
Отчет
This article considers possibilities of achieving the most effective therapeutic effect of intermittent hypoxia training (IHT) by initiating an activation and training reaction. Thanks to IHT the body builds an anti-stress type adaptation which increases the body's nonspecific resistance to the development of diseases. It works through a variable functional load which includes a mechanism for optimizing mitochondrial respiration and is a trigger for synchronizing the performance of the nervous, immune and hormonal systems. Some biochemical data presented in the article demonstrate the effects of moderate hypoxia. In addition, laboratory and hardware methods of diagnosing for the selection of individual IHT regimes are proposed. IHT is used to great effect in training of astronauts, pilots, athletes and in the treatment of diabetes mellitus, trophic ulcers, diseases of the cardiovascular system, the central nervous system and oncological disorders as well as for rejuvenation purposes.
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Internet-based interventions for cardiovascular prevention: focus on overweight and obesity
Тезисы
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Internship in the year of COVID-19: what has changed in internship dynamics?
Статья научная
The purpose of this research is to understand the changes in internship dynamics of MBA students in 2020 who undertook virtual full-time internships as compared to previous years when interns were required to be present physically. Sample was collected from two set of interns; one set interns were working through virtual internship and the second set were working on traditional model of on- site internship. For data collection, structured questionnaire was used. Data was collected on various parameters of internship processes and experience. The result from the current findings suggests that the experience of both set of interns differ significantly. This paper will essentially evaluate whether virtual full-time internships have been able to contribute, create & shape internship experience effectively for interns & understand which dimensions such as learning, productivity, communication, etc have seen changes due to the nature of work being changed. Research material in this area is limited, mainly due to students experiencing a remote working style in their internships for the first time which is why this research will be quite valuable for various stakeholders.
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Статья научная
Aims The interrelation between hemodynamic changes, functions of the cardiovascular system and biochemical reactions in the cells of the heart muscle is investigated in the present paper. Materials and Several methods were used to influence the metabolism processes in the methods myocardium. The changes in the phase functions of contraction of different cardiac muscles were recorded. In order to have comprehensive influence on the metabolism processes, normalization of the acid-base balance was performed. L-carnitine and octolipen were used to affect the lipid metabolism. Results Phase blood volumes that are characteristic of hemodynamics changed in the course of treatment to reach their nornal values. The ECG shape during the heart cycle phases also changed to reach the norm. The initial ECG shape describing Brugada syndrome almost reached its normal value. Extrasystole disappeared therewith. Conclusion The method of the heart cycle phase analysis enables monitoring any changes in hemodynamics and functions of the cardiovascular system. The method can be used for identifying the original cause of pathologies and efficient monitoring of the treatment progress.
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Interview with Vyacheslav Tyutyunnik
Ред. заметка
Sometimes history offers very interesting facts which induce thoughts to consider everything.
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Intracellular electrophysiological evidence: how pain is experienced by neurons
Статья научная
Aims. The aim hereof is to identify changes in the performance of the CNS neurons under the prolonged action of low-threshold pain factor according to indicators of the membrane potential level, parameters of the action potential and the pattern of the firing activity distribution of the neurons. Materials and methods. As a model, functionally active neurons of the central nervous system in the grape snail Helix pomatia were selected as an integral part of the organism in vivo. Used has been the author’s original electrophysiological method of continuous recording of intracellular biopotentials of animal neurons both under the background conditions and by applying a long-term low-threshold action (LTA) to the main nerves due to a graded pressure to produce a pain effect of the subthreshold level that over time turns into increasing pain. Results. For the first time in world science, objective evidence for the long-term low-intensity action of pain on the electrophysiological characteristics in a CNS neuron has been obtained. Revealed are the changes in the amplitude and the action potential firing rate, the membrane potential level and the pattern of the neuron pulse activity, traced continuously, up to full neuron potential turning-off. It has been detected that, when removing the pain factor, there are some points of return to the norm available, and, in case of longevity of the pain action, the functional state of the neuron passes the point of no return, after which the neuron electrophysiological potentials reach zero value, indicating the cessation of its life. Conclusions. The dynamics of the neuron functional state in vivo, under prolonged action of the pain factor, reflects nonlinear changes in the membrane potential, firing rate and amplitude of AP. This characterizes the phase process of forming a pathologically stable pain state of the neuron, despite the readiness of the membrane mechanisms at the transition points to a response aimed at returning to life. The evidence obtained in our experiments provides more insight into the mechanisms of chronic neurogenic pain in experimental and clinical medicine, as well as the diagnostics of the brain death.
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Статья научная
True experimental research study was conducted at Haemodialysis’ Unit at Sree Balaji Medical College and Hospital among End stage Kidney disorder patients receiving haemodialysis to determine the efficiency of ROM exercise on muscle cramps, using purposive sampling technique 12 patients for control group and 12 from experimental were selected for the study based on inclusion criteria .The experimental group were received intradialytic ROM exercise and determined the Muscle cramps by using PENNS SPASM SCALE the findings were In pretest as well as in post test, there is no major linking of experiment and control group except severity. Pre test calculated value for severity, interference and frequency c2=0.17 p=0.67, c2=0.68p=0.41, c2=0.22 p=0.90 respectively. The calculated post test value for severity was c2=4.19 p=0.05 found to be significant. Association between the demographic variables with experimental group shows the Monthly income and supportive system was having the relationship among muscle spasm and chosen demographic variables.
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Отчет
Research methodology and methods used in experiment Mars-500 held at the Institute of Biomedical Problems of the Russian Academy of Sciences in 2009-2011 are considered. 6 volunteers were isolated during 520 days in a sealed ground-based facility simulating space ship. Along with studies of the Martian crew, a number of satellite research were also carried out, which were devoted to the long-term program of medical and ecological investigations. This program was aimed at the study of the dynamics of adaptation abilities of the organism during its long stay in the natural social, living and industrial environments. For physiological investigations in experiment Mars-500, including the main experiment in a sealed ground-based facility and parallel long-term medical and ecological investigations in different regions of the world, the specialized hardwaresoftware complex "Ecosan-2007" was used. The methodology was based on the principles of prenosological diagnostics that have been further developed in the concept of adaptation risks and in the probabilistic approach to their evaluation. For evaluation of various components of the autonomous regulation state the method of heart rate variability (HRV) was used. It was concluded that the most important field in experiment Mars-500 was the investigation of the methodology of prenosological diagnostic in the preparation of a space mission to Mars.
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