Early and long-term outcomes of liver resections: a single specialized center experience

Early and long-term outcomes of liver resections: a single specialized center experience

Автор: Chichevatov D.A., Kalentjev V.V., Glukhov A.E., Seliverstova O.M., Rodina G.A., Tsyganova M.V.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Опыт работы онкологических учреждений

Статья в выпуске: 3 т.22, 2023 года.

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The purpose of the study was to evaluate the outcomes of a series of liver resections performed in a single regional specialized cancer center. Material and Methods. Eighty-nine patients underwent liver and/ or extrahepatic bile duct resections in the Penza Regional Oncology Hospital over the 8-year study period. Malignancies were observed in 81 patients. Extended liver resections (4 segments or more) were performed in 58 (65.2 %) cases. Results. Postsurgical morbidity and mortality rates were 31.5 % (28 of 89) and 6.7 % (6 of 89), respectively. Six of 10 patients with primary liver carcinomas were alive without evidence of disease progression at a follow-up time ranged from 1.0 to 76.7 months. Adjuvant chemotherapy (ACT) was the only predictor (HR=0.40; 95 % CI 0.16-0.98) of overall survival in patients with metastatic colorectal cancer (mCRC). The median survival time after liver resections for mCRC with or without ACT was 54.5 (95 % CI: 14.5-94.5) vs 21.8 months (95 % CI: 14.2-29.4), respectively. In mCRC patients with ACT, the 5-year overall survival rate was 44.8 ± 12.9 %. Conclusion. Primary hepatobiliary carcinomas and colorectal cancer liver metastases are the most common reasons for liver resections. A series of liver resections in a low-volume hospital is feasible with the achievement of good outcomes.

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Liver resection, malignant tumor, colorectal carcinoma, metastases

Короткий адрес: https://sciup.org/140300185

IDR: 140300185   |   DOI: 10.21294/1814-4861-2023-22-3-90-98

Список литературы Early and long-term outcomes of liver resections: a single specialized center experience

  • Skipenko O.G., Zavenyan Z.S., Bagmet N.N., Tsar'kov P.V., Shatveryan G.A., Polishchuk L.O., Abdullaev A.G., Makarova V.V. Rezektsiya pecheni: blizhaishie rezul'taty 132 operatsii. Annaly khirurgicheskoi gepatologii. 2006; 11(4): 23-7.
  • Vishnevskii V.A., Efanov M.G., Ikramov R.Z., Egorov V.I., Nazarenko N.A., Shevchenko T.V., Ionkin D.A., Kozyrin I.A., Kazakov I.V. Otdalennye rezul'taty rezektsii pecheni u bol'nykh s metastazami kolorektal'nogo raka i pervichnym rakom pecheni. Annaly khirurgicheskoi gepatologii. 2010; 15(1): 43-52.
  • Marwah S., Khan M.M., Chaudhary A., Gupta S., Negi S.S., Soin A., Nundy S. Two hundred and forty-one consecutive liver resections: an experience from India. HPB (Oxford). 2007; 9(1): 29-36. https://doi.org/10.1080/13651820600985259.
  • Lorenzo C.S., Limm W.M., Lurie F., Wong L.L. Factors affecting outcome in liver resection. HPB (Oxford). 2005; 7(3): 226-30. https://doi.org/10.1080/13651820510028864.
  • Lukmonov S., Usmanov O., Ismailov M., Madatov K., Kurbankulov U., Allazarov U. Immediate and long-term results of liver resections with metastatic lesion. Ann Onc. 2018; 29(5): 71-2. https://doi.org/10.1093/annonc/mdy151.254.
  • Bel'skii V.A., Mol'kov A.M., Utkin I.A., Rabosina I.A., Zagainov V.E. Protokol anestezii pri obshirnykh rezektsiyakh pecheni: smena paradigmy pod vliyaniem opyta transplantatsii pecheni (obzor literatury). Annaly khirurgicheskoi gepatologii. 2016; 21(2): 39-51. https://doi.org/10.16931/1995-5464.2016239-51.
  • Grebenkin E.N., Borisova O.A., Fomin D.K., Akhaladze G.G. K voprosu o funktsional'nom rezerve pecheni. Annaly khirurgicheskoi gepatologii. 2017; 22(1): 25-31. https://doi.org/10.16931/1995-5464.2017125-31.
  • Krasnodebski M., Bradford K.J., Wei S.H., Velasco J.D., Nishioka Y., Vauthey J.N. Chemotherapy in combination with resection for colorectal liver metastases - current evidence. Surgery in Practice and Science. 2020; 3. https://doi.org/10.1016/j.sipas.2020.100021.
  • Zagainov E.M., Seregin A.A., Zaitsev A.I., Komarov D.V., Sharabrin E.G., Rykhtik P.I., Kukosh V.M., Zagainov V.E. Sovremennye metody stimulyatsii vikarnoi gipertrofii fragmenta pecheni pered obshirnoi rezektsiei: otsenka effektivnosti i puti uluchsheniya rezul'tatov. Annaly khirurgicheskoi gepatologii. 2016; 21(3): 25-33. https://doi.org/10.16931/1995-5464.2016325-33.
  • Hamady Z.Z., Kotru A., Nishio H., Lodge J.P. Current techniques and results of liver resection for colorectal liver metastases. Br Med Bull. 2004; 70: 87-104. https://doi.org/10.1093/bmb/ldh026.
  • Eppsteiner R.W., Csikesz N.G., Simons J.P., Tseng J.F., Shah S.A. High volume and outcome after liver resection: surgeon or center? J Gastrointest Surg. 2008; 12(10): 1709-16; discussion 1716. https://doi.org/10.1007/s11605-008-0627-3.
  • Cawich S.O., Maharaj R., Naraynsingh V., Pearce N., Francis W., Bonadie K.O., Thomas D.A. Clinical outcomes after major hepatectomy are acceptable in low-volume centers in the Caribbean. World J Hepatol. 2019; 11(2): 199-207. https://doi.org/10.4254/wjh.v11.i2.199.
  • Voskanyan S.E., Artem'ev A.I., Naidenov E.V., Kolyshev I.Yu., Zabezhinskii D.A., Shabalin M.V., Bashkov A.N., Grigor'eva O.O., Shcherbin V.V., Zhurbin A.S. ALPPS v preodolenii malogo ostatochnogo ob"ema pecheni pri al'veokokkoze. Annaly khirurgicheskoi gepatologii. 2018; 23(4): 21-32. https://doi.org/10.16931/1995-5464.2018421-32.
  • Schnitzbauer A.A., Lang S.A., Goessmann H., Nadalin S., Baumgart J., Farkas S.A., Fichtner-Feigl S., Lorf T., Goralcyk A., Horbelt R., Kroemer A., Loss M., Rilmmele P., Scherer M.N., Padberg W., KonigsrainerA., Lang H., Obed A., SchlittH.J. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012; 255(3): 405-14. https://doi.org/10.1097/SLA.0b013e31824856f5.
  • Efanov M.G., Alikhanov R.B., Vishnevskii V.A. Transplantatsionnye tekhnologii v rezektsionnoi khirurgii mestnorasprostranennykh novoobrazovanii pecheni. Annaly khirurgicheskoi gepatologii. 2018; 23(4): 11-20. https://doi.org/10.16931/19955464.2018411-20.
  • Shabunin A.V., Parfenov I.P., Bedin V.V., Tavobilov M.M., Grekov D.N., Drozdov P.A., Karpov A.A. Rezektsiya pecheni. Spetsificheskie oslozhneniya i ikh profilaktika. Khirurgiya. Zhurnal imeni N.I. Pirogova. 2020; (3): 5-12. https://doi.org/10.17116/hirurgia20200315.
  • Polishchuk L.O., Kozmin L.D., Stroyakovskii D.L., Dorovskoi E.S., Skipenko O.G. Neposredstvennye rezul'taty rezektsii pecheni posle neoad"yuvantnoi khimioterapii kolorektal'nogo raka. Khirurgiya. Zhurnal im. N.I. Pirogova. 2010; (1): 30-40.
  • Soares K.C., Kamel I., Cosgrove D.P., Herman J.M., Paw-lik T.M. Hilar cholangiocarcinoma: diagnosis, treatment options, and management. Hepatobiliary Surg Nutr. 2014; 3(1): 18-34. https://doi.org/10.3978/j.issn.2304-3881.2014.02.05.
  • Balogh J., Victor D., Asham E.H., Burroughs S.G., Bok-tour M., Saharia A., Li X., Ghobrial R.M., Monsour H.P. Hepatocellular carcinoma: a review. J Hepatocell Carcinoma. 2016; 3: 41-53. https://doi.org/10.2147/JHC.S61146.
  • Bednarsch J., Czigany Z., Heij L.R., Liu D., den Dulk M., Wiltberger G., Bruners P., Ulmer T.F., Neumann U.P., Lang S.A. Compelling Long-Term Results for Liver Resection in Early Cho-langiocarcinoma. J Clin Med. 2021; 10(13): 2959. https://doi.org/10.3390/jcm10132959.
  • Gavriilidis P., Sutcliffe R.P., Hodson J., Marudanayagam R., Isaac J., Azoulay D., Roberts K.J. Simultaneous versus delayed hepatectomy for synchronous colorectal liver metastases: a systematic review and meta-analysis. HPB (Oxford). 2018; 20(1): 11-9. https://doi.org/10.1016/j.hpb.2017.08.008.
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