Ультразвуковая аблация опухоли: иммунные эффекты и перспективы интеграции в современные программы лечения генерализованного рака

Ультразвуковая аблация опухоли: иммунные эффекты и перспективы интеграции в современные программы лечения генерализованного рака

Автор: Мачак Г.Н.

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Оригинальные исследования

Статья в выпуске: 2 т.8, 2018 года.

Бесплатный доступ

Несмотря на революционные открытия последних лет в области молекулярной онкологии и иммунологии, выживаемость при генерализованных формах злокачественных новообразований не превышает 20-30 %, поэтому поиск новых терапевтических подходов остается актуальной задачей. Дальнейший прогресс, в частности, связывают с повышением иммуногенности опухолей, индукцией воспалительного фенотипа и блокадой механизмов иммуносупрессии. Решению этих задач может способствовать ультразвуковая аблация (УЗА), которая занимает особое место среди аналогичных методик, поскольку вызывает быстрый иммунный ответ, обладает неинвазивностью и низкой локальной токсичностью, позволяет манипулировать параметрами физического воздействия, допускает многократное применение, относительно недорога и не требует длительной госпитализации. Помимо циторедукции и снижения системных иммунносупрессивных сигналов, УЗА создает в организме депо лизированных клеток и считается способом вакцинирования in situ. Постаблативная иммуногенная клеточная смерть стимулирует начальные фазы иммунного цикла и способствует генерации популяций CD4+ и CD8+ цитотоксических Т-лимфоцитов...

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Злокачественные новообразования, метастазы, ультразвуковая аблация, иммунотерапия, абскопальный эффект

Короткий адрес: https://sciup.org/140243785

IDR: 140243785   |   DOI: 10.18027/2224-5057-2018-8-2-31-42

Список литературы Ультразвуковая аблация опухоли: иммунные эффекты и перспективы интеграции в современные программы лечения генерализованного рака

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