Современные иммунологические биомаркеры рака толстой кишки

Современные иммунологические биомаркеры рака толстой кишки

Автор: Трякин А.А., Хакимова Г.Г., Заботина Т.Н., Борунова А.А., Малихова О.А.

Журнал: Злокачественные опухоли @malignanttumors

Статья в выпуске: 4 т.8, 2018 года.

Бесплатный доступ

В статье кратко описан механизм действия иммунотерапевтических препаратов, подавляющих активность «чекпоинтов» иммунного ответа CTLA-4 и PD-1. Приведены современные данные о клинической эффективности и преимуществах применения ниволумаба, пембролизумаба и атезолизумаба при колоректальном раке. Обобщена существующая доказательная база о потенциальной предиктивной и прогностической роли MSI-статуса и представлена информация о перспективах дальнейшего развития данного метода лекарственного лечения злокачественных опухолей.

Лекарственная терапия, иммунотерапия, чекпоинты, ниволумаб, пембролизумаб, атезолизумаб, биомаркеры, эффективность, сhemotherapy

Короткий адрес: https://sciup.org/140243807

IDR: 140243807   |   DOI: 10.18027/2224-5057-2018-8-4-50-58

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