Проблема суицида при шизофрении: в фокусе внимания семья больного (обзор литературы)

Автор: Симак О.Я.

Журнал: Суицидология @suicidology

Статья в выпуске: 4 (33) т.9, 2018 года.

Бесплатный доступ

В статье приведены современные данные о суицидальном риске при шизофрении с точки зрения теории биопсихосоциального подхода. Материалы были получены путём поиска в электронных базах данных: Pub Med, Scopus, Wiley Online Library, e-LIBRARY. Результаты: 44,3% пациентов с шизофренией имели хотя бы одну попытку самоубийства в течение жизни; до 4,9% погибают от суицида, при этом большая часть фатальных случаев приходится на первые годы болезни. Известно, что генетические факторы объясняют 43% суицидального поведения, остальные 57% - факторами окружающей среды. По данным 2005 г. достоверными факторами риска самоубийства при шизофрении являлись: депрессивные расстройства в анамнезе (Отношение шансов (ОШ)=3,03; 95% Доверительный интервал (ДИ) 2,06-4,46), попытки суицида в анамнезе (ОШ=4,09; 95% ДИ 2,79-6,01), злоупотребление наркотиками (ОШ=3,21; 95% ДИ 1,99-5,17), возбуждение или двигательное беспокойство (ОШ=2,61; 95% ДИ 1,54-4,41), страха психического распада (ОШ=12,1; 95% ДИ 1,89-81,3), плохое соблюдение режима лечения (ОШ=3,75; 95% ДИ 2,20-6,37) и недавние потери (OШ=4,03; 95% ДИ 1,37-11,8)...

Еще

Суицид, шизофрения, семья, биопсихосоциальный подход, факторы риска

Короткий адрес: https://sciup.org/140237149

IDR: 140237149   |   DOI: 10.32878/suiciderus.18-09-04(33)-17-28

Список литературы Проблема суицида при шизофрении: в фокусе внимания семья больного (обзор литературы)

  • Предотвращение суицидов. Глобальный императив. Всемирная Организация Здравоохранения, 2014. 97 с.
  • URL: http://www.who.int/ru/news-room/fact-sheets/detail/suicide
  • URL: http://www.gks.ru/free_doc/new_site/population/demo/smert.htm
  • Bertolete J.M., Fleischmann A. Suicide and psychiatric diagnosis: a worldwide perspective. World psychiatry. 2002; 1 (3): 181-185.
  • Castagnini A., Foldager L., Bertelsen A. Excess mortality of acute and transient psychotic disorders: comparison with bipolar affective disorder and schizophrenia. Acta psychiatrica Scandinavica. 2013; 128: 370-375 DOI: 10.1111/acps.12077
  • Saglam A. D., Civil A. F., Özkorumak K. E. et al. Current clinical variables in schizophrenia cases with suicide attempt history. Türkpsikiyatri dergisi. 2017; 28 (3): 163-171. (In Turkish)
  • Солдаткин В.А., Бобков А.С., Анциборов А.В. О роли фантазий о смерти у больных шизофренией с гомицидным поведением. Тюменский медицинский журнал. 2013; 15 (1): 26-27.
  • Palmer B.A., Pankratz V.S., Bostwick J.M. The lifetime risk of suicide in schizophrenia: a reexamination. Archives of general psychiatry. 2005; 62 (3): 247-253 DOI: 10.1001/archpsyc.62.3.247
  • Rantanen H., Koivisto A.M., Salokangas R.K. et al. Five-year mortality of Finnish schizophrenia patients in the era of deinstitutionalization. Social psychiatry and psychiatric epidemiology. 2009; 44 (2): 135-42 DOI: 10.1007/s00127-008-0414-1
  • Cheng K., Leung C., Lo W. et al. Suicide Among Chinese Schizophrenics in Hong Kong. British Journal of Psychiatry. 1989; 154 (2): 243-246 DOI: 10.1192/bjp.154.2.243
  • Loas G., Azi A., Noisette C. et al. Fourteen-year prospective follow-up study of positive and negative symptoms in chronic schizophrenic patients dying from suicide compared to other causes of death. Psychopathology. 2009; 42 (3): 185-189 DOI: 10.1159/000209331
  • Jovanovic N., Podlesek A., Medved V. et al. Association between psychopathology and suicidal behavior in schizophrenia. A crosssectional study of 509 participants. Crisis. 2013; 1; 34 (6): 374381 DOI: 10.1027/0227-5910/a000211
  • Фролова Ю.Г. Биопсихосоциальная модель как концептуальная основа психологического здоровья. Философия и социальные науки: научный журнал. 2008; 4: 60-65.
  • Brent D.A., Mann J.J. Family genetic studies, suicide, and suicidal behavior. American Journal of Medical Genetics part C Seminars in Medical Genetics. 2005; 133C (1): 13-24 DOI: 10.1002/ajmg.c.30042
  • Pompili M., Amador X.F., Girardi P. et al. Suicide risk in schizophrenia: learning from the past to change the future. Annals of general psychiatry. 2007; 6 (10) DOI: 10.1186/1744-859X-6-10
  • Уманский М.С., Хохлов М.С., Зотова Е.П., Быкова А.А., Лончакова И.В. Завершённые суициды: соотношение мужчин и женщин. Академический журнал Западной Сибири. 2018; 14 (3): 76-78. мье и ближайшему окружению, участвовать в последующем оказании помощи, бороться со стигматизацией диагноза «шизофрения».
  • Психологическая терапия, направленная на улучшение навыков преодоления трудностей у пациентов и меры по борьбе со стигматизацией среди населения, направленные на сокращение случаев дискриминации, могут обеспечить определённую защиту от самоубийств среди лиц с психическими расстройствами.
  • Castagnini A., Foldager L., Bertelsen A. Excess mortality of acute and transient psychotic disorders: comparison with bipolar affective disorder and schizophrenia. Acta psychiatrica Scandinavica. 2013; 128: 370-375 DOI: 10.1111/acps.12077
  • Saglam A. D., Civil A. F., Özkorumak K. E. et al. Current clinical variables in schizophrenia cases with suicide attempt history. Türk psikiyatri dergisi. 2017; 28 (3): 163-171. (In Turkish)
  • Soldatkin VA., Bobkov А., Аntsiborov А. O roli fantazij o smerti u bol'nykh shizofreniej s gomitsidnym povedeniem . Tyumenskij meditsinskij zhurnal . 2013; 15 (1): 26-27. (In Russ)
  • Palmer B.A., Pankratz V.S., Bostwick J.M. The lifetime risk of suicide in schizophrenia: a reexamination. Archives of general psychiatry. 2005; 62 (3): 247-253 DOI: 10.1001/archpsyc.62.3.247
  • Rantanen H., Koivisto A.M., Salokangas R.K. et al. Five-year mortality of Finnish schizophrenia patients in the era of deinstitutionalization. Social psychiatry and psychiatric epidemiology. 2009; 44 (2): 135-42 DOI: 10.1007/s00127-008-0414-1
  • Cheng K., Leung C., Lo W. et al. Suicide Among Chinese Schizophrenics in Hong Kong. British Journal of Psychiatry. 1989; 154 (2): 243-246 DOI: 10.1192/bjp.154.2.243
  • Loas G., Azi A., Noisette C. et al. Fourteen-year prospective follow-up study of positive and negative symptoms in chronic schizophrenic patients dying from suicide compared to other causes of death. Psychopathology. 2009; 42 (3): 185-189 DOI: 10.1159/000209331
  • Jovanovic N., Podlesek A., Medved V. et al. Association between psychopathology and suicidal behavior in schizophrenia. A crosssectional study of 509 participants. Crisis. 2013; 1; 34 (6): 374381 DOI: 10.1027/0227-5910/a000211
  • Frolova Yu.G. Biopsikhosotsial'naya model' kak kontseptual'naya osnova psikhologicheskogo zdorov'ya Filosofiya i sotsi-al'nye nauki: nauchnyj zhurnal . 2008; 4: 60-65. (In Russ)
  • Brent D.A., Mann J.J. Family genetic studies, suicide, and suicidal behavior. American Journal of Medical Genetics part C Seminars in Medical Genetics. 2005; 133C (1): 13-24 DOI: 10.1002/ajmg.c.30042
  • Pompili M., Amador X.F., Girardi P. et al. Suicide risk in schizophrenia: learning from the past to change the future. Annals of generalpsychiatry. 2007; 6 (10) DOI: 10.1186/1744-859X-6-10
  • Umansky M.S., Khokhlov M.S., Zotov E.P., Bykova A.A., ILonchakova.V. Suicides: the ratio of men and women. Academic Journal of West Siberia. 2018; 14 (3): 76-78.
  • Lyu J., Zhang J. Characteristics of schizophrenia suicides compared with suicides by other diagnosed psychiatric disorders and those without a psychiatric disorder. Schizophrenia research. 2014; 155 (1-3): 59-65 DOI: 10.1016/j.schres.2014.02.018
  • Fuller-Thomson E., Hollister B. Schizophrenia and suicide attempts: findings from a representative community-based Canadian sample. Schizophrenia research and treatment. 2016 DOI: 10.1155/2016/3165243
  • Bani-Fatemi A., Jeremian R., Wang K.Z. et al. Epigenome-wide association study of suicide attempt in schizophrenia. Journal of Psychiatric Research. 2018; 104: 192-197 DOI: 10.1016/j.jpsychires.2018.07.011
  • Bondy B., Buettner A., Zill P. Genetics of suicide. Molecular Psychiatry. 2006; 11: 336-351 DOI: 10.1038/sj.mp.4001803
  • Clayden R.C., Zaruk A., Meyre D. et al. The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis. Translational Psychiatry. 2012; 2 (10) DOI: 10.1038/tp.2012.96
  • de Medeiros A.V., Bezerra D.G., de Andrade T.G. et al. Genetic polymorphisms might predict suicide attempts in mental disorder patients: a systematic review and meta-analysis. CNS & neurological disorders drug targets. 2015; 14 (7): 820-827 DOI: 10.2174/1871527314666150713104619
  • Zhang H., Wei X., Tao H. et al. Opposite effective connectivity in the posterior cingulate and medial prefrontal cortex between first-episode schizophrenic patients with suicide risk and healthy controls. Public Library of Science one. 2013; 21;8 (5). Print 2013 DOI: 10.1371/journal.pone.0063477
  • Minzenberg M.J., Lesh T., Niendam T. et al. Frontal motor cortex activity during reactive control is associated with past suicidal behavior in recent-onset schizophrenia. Crisis. 2015; 36 (5): 363370 DOI: 10.1027/0227-5910/a000335
  • Левашкина И.М., Серебрякова С.В., Ефимцев А.Ю. Диффузионно-тензорная МРТ -современный метод оценки микроструктурных изменений вещества головного мозга (обзор литературы). Вестник Санкт-Петербургского университета. 2016; 11 (4): 39-54.
  • Lee S.J., Kim B., Oh D. et al. White matter alterations associated with suicide in patients with schizophrenia or schizophreniform disorder. Psychiatry research. Neuroimaging. 2016; 248: 23-29 DOI: 10.1016/j.pscychresns.2016.01.011
  • Солдаткин В.А., Бухановский А.О., Калмыков А.Е. Нейровизуализационная характеристика головного мозга больных, страдающих игровой зависимостью. Российский психиатрический журнал. 2011; 1: 15-22.
  • Психиатрия. Ростовская научно-педагогическая школа в 2 т. Том II: Учебник/Под ред. В.А. Солдаткина. Ростов н/Д: Профпресс, 2018. 668 с.
  • Besteher B., Wagner G., Koch K. et al. Pronounced prefrontotemporal cortical thinning in schizophrenia: Neuroanatomical correlate of suicidal behavior? Schizophrenia Research. 2016; 176 (2-3): 151-157 DOI: 10.1016/j.schres.2016.08.010
  • Rüsch N., Spoletini I., Wilke M. et al. Inferior frontal white matter volume and suicidality in schizophrenia. Psychiatry research. 2008; 164 (3): 206-214 DOI: 10.1016/j.pscychresns.2007.12.011
  • Giakoumatos C.I., Tandon N., Shah J. et al. Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders? Journal of psychiatric research. 2013; 47 (10): 1389-1395 DOI: 10.1016/j.jpsychires.2013.06.011
  • Spoletini I., Piras F., Fagioli S. et al. Suicidal attempts and increased right amygdala volume in schizophrenia. Schizophrenia Research. 2011; 125 (1): 30-40 DOI: 10.1016/j.schres.2010.08.023
  • Jose J., Nandeesha H., Kattimani S. et al. Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia. Clinica chimica acta; international journal of clinical chemistry. 2015; 444: 78-
  • Besnier N., Gavaudan G., Navez A., et al. Clinical features of suicide occurring in schizophrenia (I). Risk-factors identification. Encephale. 2009; 35 (2): 176-181. (In French) DOI: 10.1016/j.encep.2008.02.009
  • Hawton K., Sutton L., Haw C. et al. Schizophrenia and suicide: Systematic review of risk factors. British Journal of Psychiatry. 2005; 187 (1): 9-20 DOI: 10.1192/bjp.187.1.9
  • Yan F., Xiang Y.T., Hou Y.Z. et al. Suicide attempt and suicidal ideation and their associations with demographic and clinical correlates and quality of life in Chinese schizophrenia patients. Social psychiatry and psychiatric epidemiology. 2013; 48 (3): 447-454 DOI: 10.1007/s00127-012-0555-0
  • Kilicaslan E.E., Esen A.T., Kasal M.I. et al. Childhood trauma, depression, and sleep quality and their association with psychotic symptoms and suicidality in schizophrenia. Psychiatry research. 2017; 258: 557-564 DOI: 10.1016/j.psychres.2017.08.081
  • Kao Y.C., Liu Y.P., Cheng T.H. et al. Subjective quality of life and suicidal behavior among Taiwanese schizophrenia patients. Social psychiatry and psychiatric epidemiology. 2012; 47 (4): 523-532 DOI: 10.1007/s00127-011-0361-0
  • Ishii T., Hashimoto E., Ukai W. et al. Characteristics of attempted suicide by patients with schizophrenia compared with those with mood disorders: a case-controlled study in Northern Japan. Public Library of Science one. 2014; 9 (5) DOI: 10.1371/journal.pone.0096272
  • Iancu I., Bodner E., Roitman S. et al. Impulsivity, aggression and suicide risk among male schizophrenia patients. Psychopathology. 2010; 43 (4): 223-229 DOI: 10.1159/000313520
  • Goktekin M.C., Atescelik M., Gurger M. et al. Demographical characteristics of patients attempting suicide and factors having impact on recurrent suicide attempts. Current Medicine Research and Practice. 2018; 8 (5): 165-169. https://doi.org/10.1016/j.cmrp.2018.09.004
  • Попов Ю.В., Пичиков А.А. Суицидальное поведение у подростков. СПб: СпецЛит, 2017. 366 с.
  • Turecki G. Dissecting the suicide phenotype: the role of impulsive-aggressive behaviours. Journal of psychiatry and neuroscience. 2005; 30 (6): 398-408.
  • Baud P. Personality traits as intermediary phenotypes in suicidal behavior: genetic issues. American journal of medical genetics. Part C, Seminars in medical genetics. 2005; 133 C (1): 34-42 DOI: 10.1002/ajmg.c.30044
  • Modestin J., Zarro I., Waldvogel D. A study of suicide in schizophrenic in-patients. British Journal of Psychiatry. 1992; 160 (3): 398-401 DOI: 10.1192/bjp.160.3.398
  • Drake R.E., Gates C., Cotton P.G. et al. Suicide among schizophrenics: Who is at risk? The Journal of nervous and mental disease. 1984; 172: 613-618.
  • Rüsch N., Corrigan P.W., Heekeren K. et al. Well-being among persons at risk of psychosis: the role of self-labeling, shame, and stigma stress. Psychiatric services: a journal of the American Psychiatric Association. 2014; 65 (4): 483-489 DOI: 10.1176/appi.ps.201300169
  • Patelaros E., Zournatzis E., Kontstantakopoulos G. Relationship of insight with depression and suicidal ideation in psychotic disorders. Psychiatriki. 2015; 25 (4): 265-72. (In Greek)
  • Vrbova K., Prasko J., Ociskova M. et al. Insight in schizophrenia -a double-edged sword? Neuro endocrinology letters. 2017; 38 (7): 457-464.
  • Belvederi M. M., Amore M., Calcagno P. et al. The "Insight paradox" in schizophrenia: magnitude, moderators and mediators of the association between insight and depression. Schizophrenia bulletin. 2016; 42 (5): 1225-1233 DOI: 10.1093/schbul/sbw040
  • Ouzir M., Azorin J.M., Adida M. et al. Insight in schizophrenia: from conceptualization to neuroscience. Psychiatry and clinical neurosciences. 2012; 66 (3): 167-179. 1819.2012.02325. x DOI: 10.1111/j.1440-
  • Stip E., Caron J., Tousignant M. et al. Suicidal ideation and schizophrenia: contribution of appraisal, stigmatization, and cognition. Canadian journal of psychiatry. 2017; 62 (10): 726-734 DOI: 10.1177/0706743717715207
  • Farrelly S., Jeffery D., Rüsch N. et al. The link between mental
  • DOI: 10.1016/j.cca.2015.02.003
  • Pitman A.L., Rantell K., Moran P. et al. Support received after bereavement by suicide and other sudden deaths: a crosssectional UK study of 3432 young bereaved adults. BMJ Open. 2017; 7 (5) DOI: 10.1136/bmjopen-2016-014487
  • Гаврилова Е.К., Шевченко В.А., Загиев В.В. и соавт. Клинико-социальные характеристики больных шизофренией и расстройствами шизофренического спектра и задачи по их психосоциальной терапии и реабилитации. Социальная и клиническая психиатрия. 2006; 4: 10-14.
  • Rafrafi R., Zaghdoudi L., Mahbouli M. et al. Social outcome of schizophrenics in Tunisia: a transversal study of 60 patients. Encephale. 2009; 35 (3): 234-240. (In French) DOI: 10.1016/j.encep.2008.05.001
  • Draper B., Krysinska K., Snowdon J. et al. Awareness of suicide risk and communication between health care professionals and next of kin of suicides in the month before suicide. Suicide and life-threating behavior. 2018; 48 (4): 449-458. 12365 DOI: https://doi.org/10.1111/sltb
  • Mory C., Jungbauer J., Bischkopf J. et al. Financial burden on spouses of patients suffering from schizophrenia, depression or anxiety disorder. Fortschritte der Neurologie-Psychiatrie. 2002: 70(2): 71-77. (In German)
  • Awad A.G., Voruganti L.N. The burden of schizophrenia on caregivers: a review. Pharmacoeconomics. 2008; 26 (2): 149-62.
  • Корман Т.А., Бочаров В.В., Масловский С.Ю. Бремя, которое несут члены семей больных шизофренией («семейное бремя»). Журнал неврологии и психиатрии. 2012; 12: 80-85.
  • Krupchanka D., Kruk N., Sartorius N. et al. Experience of stigma in the public life of relatives of people diagnosed with schizophrenia in the Republic of Belarus. Social psychiatry and psychiatric epidemiology. 2017; 52(4): 493-501. doi: https://doi.org/10.1007/s00127-017-1365-1
  • Huang Y.-C., Hsu S.-T., Hung C.-F. et al. Mental health of caregivers of individuals with disabilities: relation to suicidal ideation. Comprehensive Psychiatry. 2018; 81: 22-27. doi: https://doi.org/10.1016/j.comppsych.2017.11.003
  • Зотов П.Б. Психотерапия при суицидальном поведении: теоретические и клинические предпосылки. Суицидология. 2017; 8 (3): 53-61.
  • Ringel E. The Presuicidal Syndrome. Suicide Life. Threat Behav. 1976; 6: 131-149.
  • Старшенбаум Г.В. Суицидология и кризисная психотерапия. М.: «Когито-центр», 2018. 336 с.
  • Образцова А.С. О группе поддержки переживающих суицид близкого. Академический журнал Западной Сибири. 2018; 14 (3): 72-74.
  • Pitman A.L., Osborn D.P.J., Rantell K. et al. The stigma perceived by people bereaved by suicide and other sudden deaths: A cross-sectional UK study of 3432 bereaved adults. Journal of psychosomatic research. 2016; 87: 22-29 DOI: 10.1016/j.jpsychores.2016.05.009
  • Kolves K., Zhao Q., Ross V. et al. Suicide and other sudden death bereavement of immediate family members: An analysis of grief reactions six-months after death. Journal of Affective Disorders. 2019; 243 (15): 96-102 DOI: 10.1016/j.jad.2018.09.018
  • Reynders A., Kerkhof A.J.F.M., Molenberghs G. et al. Attitudes and stigma in relation to help-seeking intentions for psychological problems in low and high suicide rate regions. Social psychiatry and psychiatric epidemiology. 2014; 49 (2): 231-239 DOI: 10.1007/s00127-013-0745-4
  • Fenger-Gran M., Kjaersgaard M.I.S., Parner E.T. et al. Early treatment with talk therapy or antidepressants in severely bereaved people and risk of suicidal behavior and psychiatric illness: an instrumental variable analysis. Clinical Epidemiology. 2018; 10:1013-1026. health-related discrimination and suicidality: service user perspectives. Psychological medicine. 2015; 45 (10): 2013-2022. 10.1017/S0033291714003158 DOI: 10.2147/CLEP.S157996
  • Feigelman W., Cerel J., Sanford R. Disclosure in traumatic deaths as correlates of differential mental health outcomes. Death Studies. 2018; 42: 456-462 DOI: 10.1080/07481187.2017.1372533
  • Бородин С.В., Михлин А.С. Мотивы и причины самоубийств. Актуальные проблемы суицидологии. М., 1978: 28
  • Касимова Л.Н., Втюрина М.В., Святогор М.В. Оценка факторов суицидального риска у больных шизофренией. Социальная и клиническая психиатрия. 2014; 24 (1): 10-13.
  • Wasserman D., Rihmer Z., Rujescu D. et al. The European Psychiatric Association (EPA) guidance on suicide treatment and prevention. European psychiatry: the journal of the Association of European Psychiatrists. 2012; 27 (2): 129-141 DOI: 10.1016/j.eurpsy.2011.06.003
  • Зотов П.Б., Родяшин Е.В., Петров И.М., Жмуров В.А., Шнейдер В.Э., Безносов Е.В., Севастьянов А.А. Регистрация и учёт суицидального поведения. Суицидология. 2018; 9 (2): 104-110.
  • Feigelman W., Cerel J., Sanford R. Disclosure in traumatic deaths as correlates of differential mental health outcomes. Death Studies. 2018; 42: 456-462 DOI: 10.1080/07481187.2017.1372533
  • Borodin S.V., Mikhlin А. Motivy i prichiny samoubijstv . Aktual'nyeproblemy suitsidologii . M., 1978: 28-43. (In Russ)
  • Kasimova L.N., Vtyurina M.V., Svyatogor M.V. Otsenka faktorov suitsidal'nogo riska u bol'nykh shizofreniej . Sotsi-al'naya i klinicheskaya psikhiatriya . 2014; 24 (1): 10-13. (In Russ)
  • Wasserman D., Rihmer Z., Rujescu D. et al. The European Psychiatric Association (EPA) guidance on suicide treatment and prevention. European psychiatry: the journal of the Association of European Psychiatrists. 2012; 27 (2): 129-141 DOI: 10.1016/j.eurpsy.2011.06.003
  • Zotov P.B., Rodyashin E.V., Petrov I.M., Zhmurov V.A., Shneider V.E., Beznosov E.V., Sevastianov A.A. Registration and account of suicidal behavior. Suiddology. 2018; 9 (2): 104-110. (In Russ)
Еще
Статья научная