Evaluation of recurrence risk after organ-sparing treatment of breast cancer depending on biological subtype of the tumor

In this study, based on the results of IHC of patients with reсurrence of breast cancer, the most often found molecular subtypes were analyzed and assessed their role in the development of local recurrence. Analysis of risk of recurrence of breast cancer was conducted in accordance with the molecular features of the tumor, which include the expression of estrogen receptor, progesterone receptor gene and the expression of human epidermal growth factor - HER2 / neu and proliferation activity index Ki 67. The study found that the majority of primary tumors, followed by recurrence are triple negative type (42%). Also we found the change in morphological parameters of recurrent tumor. Thus, in most cases of recurrence proliferative activity index increases by an average of 12%, about 30% of tumors have changed their morphological status.