Methods of intraoperative correction of hepatic dysfunction

Автор: Laptiyova A.Yu., Andreev A.A., Ostroushko A.P.

Журнал: Международный журнал гуманитарных и естественных наук @intjournal

Статья в выпуске: 7-3 (70), 2022 года.

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The hepatobiliary system pathology remains an urgent problem of modern medicine. The liver regeneration ability largely determines the outcome of surgery and postoperative complications. The aim of the study was to enhance the prevention of postoperative hepatic dysfunction by activating methylation processes. The study involved experimental and clinical phases. In the experimental unit, the best results (15,17% acceleration of liver mass recovery) were observed with intrahepatic administration of cyanocobalamin, and intrahepatic administration of cyanocobalamin with intraperitoneal administration of ademethionine (12,04% acceleration). In clinical conditions, intravenous administration of cyanocobalamin and ademethionine contributed to the normalization of indicators of cholestasis syndrome, hepatic cell insufficiency and inflammation, a decrease in cytolysis, hepatic cell insufficiency. Thus, the proposed method of activation of methylation processes allows to increase the reparative potential of the liver, ensures the restoration of its anatomical and functional integrity, prevents the development of postoperative hepatic dysfunction.


Hepatic dysfunction, cyanocobalamin, ademethionine, regeneration, cholecystectomy

Короткий адрес:

IDR: 170194999   |   DOI: 10.24412/2500-1000-2022-7-3-27-29

Список литературы Methods of intraoperative correction of hepatic dysfunction

  • Grek A., Arasi L. Acute Liver Failure. AACN Adv Crit Care. 2016 Oct;27(4):420-429. DOI: 10.4037/aacnacc2016324. PMID: 27959298
  • Bernal W, Auzinger G, Dhawan A, Wendon J. Acute liver failure. Lancet. 2010 Jul 17;376(9736):190-201.
  • DOI: 10.1016/S0140-6736(10)60274-7. PMID: 20638564
  • Soreide J.A., Deshpande R. Post hepatectomy liver failure (PHLF) - Recent advances in prevention and clinical management. Eur J Surg Oncol. 2021 Feb;47(2):216-224. Epub 2020 Sep 10. DOI: 10.1016/j.ejso.2020.09.001 PMID: 32943278
  • Laptiyova A.Yu., Andreev A.A., Glukhov A.А., Atiakshin D.A., Ostroushko A.P., Boyev S.N., Nikishina T.G., Mikulich E.V., Koshelev P.I., Andreeva E.A. Prevention of post-resection acute liver failure by various methods of cyanocobalamin administration in the experiment // International Journal of Biomedicine. 2020. Т. 10. № 3. С. 257-261.
  • Rahbari N.N., Garden O.J., Padbury R., Brooke-Smith M., Crawford M., Adam R., Koch M., Makuuchi M., Dematteo R.P., Christophi C., Banting S., Usatoff V., Nagino M., Maddern G., Hugh T.J., Vauthey J.N., Greig P., Rees M., Yokoyama Y., Fan S.T., Nimura Y., Figueras J., Capussotti L., Büchler M.W., Weitz J. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011 May;149(5):713-24. Epub 2011 Jan 14. DOI: 10.1016/j.surg.2010.10.001 PMID: 21236455
  • Schreckenbach T, Liese J, Bechstein WO, Moench C. Posthepatectomy liver failure. Dig Surg. 2012;29(1):79-85. Epub 2012 Mar 15. DOI: 10.1159/000335741 PMID: 22441624
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