Медикаментозное лечение стабильной стенокардии: место триметазидина

Автор: Темникова Е.А.

Журнал: Евразийский кардиологический журнал @eurasian-cardiology-journal

Рубрика: Обзор

Статья в выпуске: 4, 2022 года.

Бесплатный доступ

По данным международных эпидемиологических исследований, общее число зарегистрированных случаев сердечно-сосудистых заболеваний (ССЗ), с 1990 г. по 2019 г. возросло практически в два раза, достигнув 523 миллионов, а количество смертей от ССЗ в 2019 году увеличилось более, чем в полтора раза (18,6 миллионов). Основной вклад в это вносят ишемическая болезнь сердца (ИБС) и инсульт. В 2019 г. зарегистрировано 197 миллионов случаев ИБС, а количество смертей, вызванных ею, превысило половину всех случаев сердечно-сосудистой смертности (9,14 миллионов). Пациенты со стабильной стенокардией составляют большую часть больных с ИБС. Несмотря на существующие современные методы лечения пациенты с хронической ИБС продолжают страдать от ангинальных болей, что значительно снижает их толерантность к физическим нагрузкам и ухудшает качество жизни. В клинической практике, как показывают исследования, тяжесть и частота стенокардии у пациентов остаются недооцененными врачами, соответственно своевременно не корректируется медикаментозная терапия, не используются в полном объёме возможности комбинированной антиангинальной терапии. Триметазидин как антиангинальный препарат, действующий на метаболизм ишемизированной миокардиальной клетки (влияние на ишемический каскад путём уменьшения клеточного ацидоза и увеличения содержания АТФ), доказал свою эффективность и безопасность при лечении стенокардии независимо от механизма, вызвавшего ишемию при монотерапии и в комбинации, прежде всего с бета-адреноблокаторами (БАБ).

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Ишемия миокарда, стенокардия, качество жизни при стенокардии, антиангинальная терапия, триметазидин

Короткий адрес: https://sciup.org/143179495

IDR: 143179495   |   DOI: 10.38109/2225-1685-2022-4-82-89

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