Клинико-генетическая гетерогенность меланомы кожи

Клинико-генетическая гетерогенность меланомы кожи

Автор: Любченко Л.Н., Черненко П.А., Хатырев С.А., Емельянова М.А., Наседкина Т.В., Писарева Е.Е., Коваленко С.П., Шаманин В.А.

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Молекулярно-генетические аспекты диагностики

Статья в выпуске: 2 т.2, 2012 года.

Бесплатный доступ

Меланома кожи (МК) является этиологически гетерогенным заболеванием, развитие которого связано с воздействием как средовых, так и генетических факторов. С использованием сегрегационного анализа и сравнительной геномной гибридизации были выделены наследственные онкологические синдромы, на фоне которых развивается МК, и картированы гены, вовлеченные в наследственный канцерогенез МК. В молекулярный патогенез спорадической МК вовлечены онкогены и гены-супрессоры, входящие в состав различных сигнальных каскадов. гиперактивация сигнального пути RAS-RAF-MEK-MAPK наблюдается до 90% случаев МК человека, при этом соматические мутации в гене BRAF являются определяющими в 50- 70% случаев МК.

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Меланома кожи, наследственные онкологические синдромы, соматические мутации гена braf

Короткий адрес: https://sciup.org/14045438

IDR: 14045438

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