Иммунотерапия злокачественных глиом: современное состояние проблемы и перспективные направления

Иммунотерапия злокачественных глиом: современное состояние проблемы и перспективные направления

Автор: Борисов К.Е., Сакаева Д.Д.

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Диагностика и лечение опухолей. Состояние проблемы

Статья в выпуске: 2 (13), 2015 года.

Бесплатный доступ

Несмотря на агрессивное мультимодальное лечение прогноз при злокачественных глиомах остается плохим. Низкая эффективность традиционной цитостатической терапии вынуждает искать альтернативные подходы к лечению. В данном обзоре рассматриваются вопросы активной иммунотерапии с помощью противоопухолевых вакцин и адоптивной клеточной терапии. Вакцинотерапия может осуществляться с использованием опухолевых лизатов или отдельных пептидов или мРНК. Для улучшения иммуногенности вакцины используются дендритные клетки и различные иммуноадъюванты. При использовании лизатной вакцины при вновь выявленной мультиформной глиобластоме медиана выживаемости без прогрессирования составляет 9,5-18 месяцев, а медиана общей выживаемости 16,25-35,9 месяца, что значительно выше, чем в историческом контроле. Среди пептидных вакцин изучаются вакцины к WT-1, сурвивину, мутированному варианту изоцитратдегидрогеназы (IDHR132H), мутированному варианту рецептора эпидермального фактора роста (EGFRvIII). Перспективными представляются методы вакцинотерапии против антигенов стволовых клеток глиом, цитомегаловирусных антигенов. Активно изучается возможность интеграции иммунотерапии в существующие стандарты лечения, а также комбинация нескольких иммунотерапевтических стратегий.

Еще

Злокачественные глиомы, иммунотерапия, вакцины, дендритные клетки

Короткий адрес: https://sciup.org/14045527

IDR: 14045527

Список литературы Иммунотерапия злокачественных глиом: современное состояние проблемы и перспективные направления

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