Хронодиагностика и хронотерапия - основа персонализированной медицины

Хронодиагностика и хронотерапия - основа персонализированной медицины

Автор: Губин Денис

Журнал: Тюменский медицинский журнал @tmjournal

Статья в выпуске: 1 т.21, 2019 года.

Бесплатный доступ

В современных реалиях игнорирование фактора времени при диагностике и лечении заболеваний становится анахронизмом. Большинство функционально важных генов проявляет циркадную (околосуточную) ритмичность на всех этапах экспрессии. Как следствие существование выраженной суточной динамики большинства клинических показателей означает одно - незнание, или непонимание закономерностей суточной динамики неизбежно будет приводить к неверной интерпретации результатов и высокой частоте ошибок диагностики. Кроме того, динамика физиологических показателей при развитии патологии изменяется, в различной степени утрачивая свою регулярность. Особый интерес для развития методов хронодиагностики представляют исследования амплитудно-фазовых параметров циркадного ритма. С другой стороны, время назначения препарата или иного терапевтического, либо профилактического воздействия может критически влиять на его результат. Определяющими условиями для трансляции фундаментальных знаний хронобиологии в практическое здравоохранение (хрономедицину) являются: 1). Разработка универсальных критериев методологии сбора, анализа и интерпретации результатов динамических наблюдений и 2). Разработка простого, но точного метода оценки фазы биологических часов (фазы эндогенного циркадного ритма). В данной работе проведен сравнительный анализ существующих методов оценки фазы циркадианного ритма и рассмотрены перспективы реализации тактики персонализированной хронодиагностики и хронотерапии.

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Суточный ритм, циркадианный, циркадный, биологические часы, диагностика, терапия, персонализированная медицина, хронотип, фаза, амплитуда, циркадный фенотип, синхронизация, десинхроноз

Короткий адрес: https://sciup.org/140244776

IDR: 140244776   |   DOI: 10.36361/2307-4698-2019-21-1-20-40

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