Холангиоцеллюлярная карцинома сегодня. Литературный аналитический обзор

Холангиоцеллюлярная карцинома сегодня. Литературный аналитический обзор

Автор: Ротин Даниил Леонидович

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Фундаментальная онкология и экспериментальная медицина

Статья в выпуске: 3 (14), 2015 года.

Бесплатный доступ

Холангиокарцинома (ХГК) представляет собой группу злокачественных опухолей с признаками дифференцировки в направлении эпителия желчных путей. Анатомически ХГК подразделяют на внутрипеченочные, воротные и дистальные. Данные подтипы различаются не только по локализации, но и по эпидемиологии, этиологии, патогенезу и лечению. Частота встречаемости и смертность от ХГК за последние десятилетия существенно выросли, в то время как выживаемость остается низкой. В разных географических областях вариации ХГК обусловлены различными факторами риска. В последние годы накоплены данные по генетическим изменениям клеток ХГК, кроме того обнаружено что строма этой опухоли содержит множество карциномазависимых фибробластов (КЗФ), стимулирующих развитие и рост опухоли. В характеристике и понимании онкогенезавнутрипеченочной ХГК и воротной ХГК отмечается существенный прогресс. Пациентов с внутрипеченочной ХГК обычно лечат хирургически. Для воротной ХГК основным методом лечения является трансплантация печени с неоадъювантной химиотерапией. Предлагаем обзор современного понимания эпидемиологии, патогенеза, классификации, взглядов на диагностику и лечение ХГК.

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Холангиокарцинома, онкология, молекулярная патология, лечение опухолей

Короткий адрес: https://sciup.org/140223361

IDR: 140223361   |   DOI: 10.18027/2224-5057-2015-3-3-16

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