Four secondary malignancies, coronary artery disease, aortic atherosclerosis and severe constrictive pericarditis in a survivor of Hodgkin lymphoma treated with radiation therapy: a case report

Автор: Jeri-yabar A., Garazatua-gonzalez J., Montoya-rivera W., Ortuzar-seminario V., Lozada Zingoni C., Massuco V.

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Случай из клинической практики

Статья в выпуске: 1 т.22, 2023 года.

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Introduction. Radiation therapy (RT) has been widely used since the 1970s in the treatment of Hodgkin’s lymphoma. RT increases the risk of secondary malignancies and heart disease including coronary artery disease, noncoronary atherosclerotic valvular disease, valvular dysfunction, pericardial disease and radiation induced vasculopathy. Case Presentation. We describe a case of a patient with 4 secondary malignancies due to previous RT including parotid mucoepidermoid carcinoma, breast multicentric infiltrating ducta, thyroid papillary microcarcinoma with follicular pattern and lung adenocarcinoma that later presented with severe constrictive pericarditis, which led to an emergency pericardiectomy - all of these were complications of her previous radiotherapy. She received a prompt diagnosis and treatment. Discussion. Radiation-induced vascular disease (RIVD) occurs due to endothelial injury following RT; patients have up to 3-4 fold increase in risk of myocardial infarction due to CAD, therefore screening of CAD with a CT coronary angiography is recommended to begin 5 years after receiving RT in patients 45 and older and 10 years after RT in patients

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Radiation therapy, radiation pericarditis, secondary malignancies

Короткий адрес: https://sciup.org/140297840

IDR: 140297840   |   DOI: 10.21294/1814-4861-2023-22-1-159-165

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