Fish-метод: способ цитогенетической ретроспективной оценки дозы

Автор: Нугис В.Ю.

Журнал: Саратовский научно-медицинский журнал @ssmj

Рубрика: Радиационная медицина

Статья в выпуске: 4 т.12, 2016 года.

Бесплатный доступ

Представлен обзор данных научной литературы, посвященной FISH-методу как способу ретроспективной оценки дозы. Рассмотрены проблемы ретроспективной цитогенетической оценки дозы в целом; молекулярно-биологических основ FISH-метода; видов аберрации хромосом, идентифицируемых с помощью FISH-метода; принципов построения дозовых кривых для FISH-регистрируемых транслокаций хромосом. Сделан вывод о необходимости привлечения трехцветного и многоцветного вариантов методики к ретроспективной оценке дозы.

Fish-метод, аберрации хромосом, культура лимфоцитов периферической крови, оценка дозы

Короткий адрес: https://sciup.org/14918385

IDR: 14918385

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