Blood serum cytokine status in ovarian cancer patients with different levels of circulating tumor cells

Автор: Gening Snezhanna Olegovna, Abakumova Tatyana Vladimirovna, Antoneeva Inna Ivanovna, Gafurbaeva Dina Urkhanovna, Miftakhova Regina Rivkatovna, Dolgova Dinara Rishatovna, Peskov Andrey Borisovich

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Клиническая медицина

Статья в выпуске: 4, 2019 года.

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Circulating tumor cells (CTCs) are essential for hematogenous metastasis. In 2003, it was found out that such cells were present in the blood of patients diagnosed with ovarian cancer (OC). It is known that inflammation plays an important role in tumor progression. There are CSCs with a large number of components in the blood, e.g. cytokines that can modulate the metastatic potential of a tumor cell. The aim of the study is to assess the blood serum cytokine status in ovarian cancer patients with different levels of circulating tumor cells. Materials and Methods. Untreated primary patients (n=24) with histologically or cytologically verified ovarian cancer, stage II-IV according to FIGO classification, were the trial subjects. Flow cytometry was used to detect the number of circulating tumor cells in the blood from the patients; the authors also determined IL-6, IL-17A, IL-1ft, TGF-a, IL-4, VEGF, TNF-a, HGF, IL-18, IL-10, IL-8 levels. The results were processed using the Statistica Windows software package...

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Ovarian cancer, cytokines, circulating tumor cells

Короткий адрес: https://readera.org/14116402

IDR: 14116402   |   DOI: 10.34014/2227-1848-2019-4-50-62

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