Церамиды: взаимосвязь с факторами риска сердечно-сосудистых заболеваний

Церамиды: взаимосвязь с факторами риска сердечно-сосудистых заболеваний

Автор: Е.В. Белик, Ю.А. Дылева, О.В. Груздева

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Рубрика: Обзоры и лекции

Статья в выпуске: 1 т.38, 2023 года.

Бесплатный доступ

Несмотря на достигнутые успехи, ведущей причиной смертности во всем мире остаются сердечно-сосудистые заболевания (ССЗ). С помощью традиционных факторов риска не всегда возможно выявить всех пациентов с высокой вероятностью развития сердечно-сосудистых событий (CCC), поэтому до сих пор остается актуальной проблема поиска новых биомаркеров ССЗ. Ранее проведенные исследования показали важную роль избыточного синтеза церамидов в развитии ожирения, инсулинорезистентности (ИР), сахарного диабета 2-го типа (СД2), стеатоза печени. Считается, что церамиды способны модулировать сигнальные пути, участвующие в регуляции метаболизма глюкозы, синтеза триацилглицеролов (ТАГ), развитии апоптоза, фиброза и атеросклероза. Учитывая широкий спектр метаболических эффектов, изучение церамидов является перспективным для выявления пациентов высокого риска ССЗ и улучшения существующих лечебно-диагностических стратегий. В этой обзорной статье рассмотрена роль церамидов в развитии атеросклероза, взаимосвязь с традиционными факторами риска, а также возможность их использования в качестве новых факторов риска для ранней диагностики ССЗ.

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Церамиды, факторы риска, сердечно-сосудистые заболевания, курение

Короткий адрес: https://sciup.org/149141578

IDR: 149141578   |   DOI: 10.29001/2073-8552-2023-38-1-28-36

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