Biomarkers of kidney injury in children with leukemia after anticancer therapy

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The paper deals with the problem of kidney injury in children with leukemia after anticancer therapy. It is stated that cancer incidence has a steady growing trend all over the world, including the children population of Russia. It is reported that a significant proportion of childhood cancer survivors suffer serious late complications, including heart failure, neurotoxicity, nephrotoxicity, growth failure, hormonal disorders, and secondary cancers. Therefore, current research is focused on the problems of early diagnosis even in the "asymptomatic" period of the disease. Special attention is paid to early diagnosis of kidney disorder in children with leukemia who have received anti-cancer treatment. The aim of research was to study the markers of kidney damage after completion of polychemotherapy and radiation therapy. The results obtained demonstrate that in the first two years after completion of anticancer therapy children with acute lymphoblastic leukemia (ALL) had an increased level of urinary kidney damage-1 molecule (KIM-1). It is highlighted that further long-term follow-up studies are necessary to assess the significance of the urinary KIM-1 and cystatin C in the blood serum and their relationship to kidney damage after anticancer treatment in childhood.

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Leukemia, children, anticancer therapy, nephrotoxicity, biomarkers, kidney damage, ckd

Короткий адрес: https://readera.org/170195176

IDR: 170195176   |   DOI: 10.24412/2500-1000-2022-7-3-48-52

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