Corellation of laser design - microstructure - properties in porous 3D matrix for tessue engineering and drug delivery systems

Review is presented the state of art and the last authors results by the layer by layer laser syntheses of 3D porous scaffolds. The biocompatibility of 3D matrix from nitinol (NiTi intermetallic phase) and nitinol with hydroxyapatite was studied. The correlation between computer aid modeling of 3D scaffolds, optimal regimes of laser fabrication, microstructure and their chemical biological properties are discussed. This observation carried out as a direct direction during synthesis, as an inverse direction - i.e. base on a dynamic proliferation and osteointegration results in 3D scaffolds to improve design, microstructure and material choice. Original ideas by the porous drug delivery system fabrication from shape memory nitinol are proposed.