Age-related morphological changes of glioneyronal complex in primary visual cortex of the brain of rat, correction with n-tyrosol

The experiment on 30 white male Wistar rats shows an increased percentage of neurons and gliacytes with predominantly dark type destructive changes in layers II, IV, V in primary visual cortex by 18 months age. The glioneuronal index changes due to a decreased neuron number and a subsequently increased glial number. However, a course administration of n-tyrosol to 18 months old rats leads to a decline in destructive changes compared to 18 months old rats without n-tyrosol. The percentage of hyperchromatic neurons without shrinking nucleus of 18 months rats on the background of correction also declines, which is likely to be connected with their transition to normochromic condition.