Efficiency of thermoradiation therapy in combined treatment of locally advanced laryngeal and hypopharyngeal cancers

The article presents results of combined treatment of locally advanced laryngeal and hypopharyngeal cancers, stages III-IV (Т3N0-2M0). All patients (55) were divided into 2 groups. The patients of the group 1 (25 people) were given pre-operative thermoradiation therapy, the patients of the group 2 (30 people) were given pre-operative radiation therapy only. The follow-up period lasted 6-24 months. After pre-operative treatment partial tumor regression and growth stabilization were diagnosed in 21 (84%) and 4 (16%) patients of the group 1 respectively. In the group 2 partial tumor regression and growth stabilization were diagnosed in 18 (60%) and 12 (49%) patients respectively. Local and regional recurrences were developed in 1 patient (4%) of the group 1 in the first year of follow-up and in 11 patients of the group 2, among them 7 recurrences were diagnosed in the first year and 4 - in the second year of the follow-up. Two-year overall survival was 100% in the group 1 and 76.7%±10.1% - in the group 2. Disease-free survival was 96.6±3.5% and 63.3±13.9% respectively.