Vascular disorders in obesity: risk factors and clinical features

The article presents data on vascular disorders and development of endothelial dysfunction in patients with obesity and metabolic syndrome. Considered various risk factors for obesity, in particular lipid disorders, smoking. 108 patients (90 women and 18 men) aged 43 to 65 years (mean age 54.62 ± 0.43) with obesity and metabolic syndrome development were examined. The vasomotor function of the endothelium was assessed by the method of Celermajer et al. The results of clinical studies aimed at studying early markers of endothelial dysfunction (the level of MAU, homocysteine, the state of intrarenal hemodynamics (pulsation index and resistivity index) at the level of interlobar and segmental arteries, and data from a test with reactive hyperemia) are analyzed. The processing of the obtained data was carried out using standard statistical methods. The influence of obesity, as an independent factor, on the development of endothelial dysfunction is discussed.