Prognostic role of ascitic fluid redox system parameters in patients with ovarian cancer

Ovarian cancer (OC) is a malignant neoplasm sensitive to chemotherapy (CT). AP-regimen is considered to be one of the most effective schemes for today. However, every fourth patient develops drug resistance during CT. Prognostic markers, which help to assess the effectiveness of treatment beforehand, will allow physicians to choose the optimal CT scheme. The aim of the paper is to assess the prognostic role of ascitic fluid redox system parameters in patients with advanced ovarian cancer. Materials and Methods. The study enrolled women with verified ascitic OC. All patients received neoadjuvant chemotherapy according to AP-scheme. Before treatment, ascites sampling was taken form the patients in order to determine the enzyme activity in the extracellular fraction: glutathione-S`-transferase (GT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH). Morphological changes in the tumor caused by neoadjuvant chemotherapy were assessed according to CRS`...