Peculiarities of CCND1 (BCL1) gene expression of cell cycle regulator the cyclin D1 in various brain structures during long-term memory realization in adult rats

The main goal was a comparative study of CCND1 (BCL1) gene transcriptional activity, the product of which cycline D1 participates in the regulation of the G1 phase of the cell cycle in relevant cerebral structures during the formation of long-term spatial memory in male mature rats Wistar. Methods. In behavioral experiments, 2 groups of animals were used, namely, a group of rats subjected to forced swimming (active control) and a group of trained animals, who developed the spatial skill of finding a hidden platform in the Morris water maze.Native animals of the same age and sex, not passing the experimental protocol, served as controls. In genetic experiments, real-time PCR was used to study the expression of the CCND1 (BCL1) gene in cerebral structures in groups of native rats, “active control” and trained animals. Results. It цфы shown that the criterion for establishing solid long-term memory was the fact that the time to reach the platform at the end of the 4th session on the 4th day of training was less than 10 seconds...