Methodology of validation of in silico 3D models of pharmacologically relevant proteins-targets
Автор: Yanalieva Laura R., Vasilyev Pavel M., Kochetkov Andrey N.
Журнал: Природные системы и ресурсы @ns-jvolsu
Статья в выпуске: 1 т.8, 2018 года.
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The article studies the development of methodology and results of validation of in silico 3D models of pharmacologically relevant target proteins on the example of protein kinase C theta. Using the IUPHAR / BPS database, information has been found about 5 reference inhibitors PRKCQ, recognized by the world scientific community. According to the received data, 3 most valid PRKCQ models (PDB-codes: 5F9E, 2JED, 4RA5) have been selected, which can later be used for docking of new inhibitors.
3d models of target proteins, biosensors, reference inhibitors, docking, validation, protein kinase, 3d-модели белки-мишени
Короткий адрес: https://sciup.org/149129626
IDR: 149129626 | DOI: 10.15688/jvolsu11.2018.1.16
