Clinical factors associated with non-valvular atrial fibrillation

Atrial fibrillation is the most common type of heart arrhythmia that can lead to serious complications, such as ischemic stroke and acute heart failure. Timely diagnosis is problematic in cases of paroxysmal and asymptomatic atrial fibrillation. Therefore, studying of clinical conditions associated with atrial fibrillation represents a relevant scientific problem. There are some well-studied associations including those with arterial hypertension and chronic heart failure. Meanwhile, interconnections with chronic obstructive pulmonary disease, sleep apnea, and other conditions are not so clear and require further investigation. Deep understanding of the above mechanisms will facilitate prompt diagnosis of atrial fibrillation and prevention of its complications. In this review, the epidemiology of atrial fibrillation and major mechanisms underlying relationships between non-valvular atrial fibrillation and associated conditions are highlighted.