The modification of the intestine microbiome after chronic influence of heavy metal compounds on macroorganism

It has been studied mice colon''s microbiome after effect of such heavy metals compounds as copper sulfate, zinc sulfate and lead acetate by drinking water for one hundred days. It was shown that chronic toxicity of experimental animals leaded to quantitative and structural changes in the microbiome of the intestine, which was manifested in the suppression of growth normoflora (Bifidobacterium spp., Lactobacillus spp.), while the frequency of occurrence and density of colonization of opportunistic bacteria (Klebsiella spp., Proteus spp., Enterococcus spp.) and pathogenic microbiota (Staphylococcus aureus) were increased. The most significant of dysbiotic changes have been observed in animals which got compounds of copper and zinc with drinking water. It has been found significant increase in quantity of bacteria which contained in the genotype genes of expression pathogenicity factors.