Photodynamic therapy of Ehrlich carcinoma in mice with liposomal boronated chlorin E6

This paper reports results of estimating effectiveness of the liposomal boronated chlorin e6 photosensitizer for photodynamic therapy. For the study Ehrilich carcinoma-bearing mice were used as a model. Pharmacokinetics of the photosensitizer, its accumulation in tumor and other organs and tissues was studied to determine the optimal time interval between chlorin e6 administration and laser irradiation. Effectiveness of the treatment was evaluated by the following parameters: completeness of tumor regression (%); tumor absolute growth rate in mice with the continued tumor growth; life expectancy increase (%) in tumor-bearing mice compared to the control animals; evidence of tumor recurrence during 90 days after the treatment. The study revealed high antitumor effect of photodynamic therapy with liposomal boronated chlorin e6 photosensitizer on Ehrlich carcinoma in mice. The treatment performed within the optimal time interval between the photosensitizer administration and PDT produces the highest inhibiting effect on tumor.