Effect of rosuvastatin on the parameters of microcirculation in patients with coronary artery disease

Автор: Boiko V.V., Soboleva G.N., Fedorovich A.A., Karpova I.E.

Журнал: Кардиологический вестник @kardiologicheskiy-vestnik

Рубрика: Оригинальные статьи

Статья в выпуске: 1 т.XII, 2017 года.

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Objective: Our aim was to investigate the effects of lipidlowering therapy (rosuvastatin) on skin microvascular function as the model of myocardial microcirculation in patients with coronary artery disease (CAD). Methods: This open-label single-arm study included 24 CAD patients (16 male; mean age 57.1±6.4 years), who did not receive lipid-lowering therapy for 4 weeks. At baseline and after 12 weeks of treatment with rosuvastatin 10 mg daily all patients underwent laser Doppler flowmetry (LDF) with amplitude-frequency wavelet analysis of skin blood flow oscillations. Results: At 12 weeks rosuvastatin therapy decreased mean total cholesterol level from 5.69 ± 1.17 mmol/l to 4.02 ± 1.18 mmol/l, LDL-C level from 4.14 ± 1.10 mmol/l to 2.30 ± 0.91 mmol/l (р


Microcirculation, atherosclerosis, statins, laser doppler flowmetry, wavelet analysis

Короткий адрес: https://readera.org/14334809

IDR: 14334809

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