Современное состояние молекулярно-генетических исследований в суицидологии и новые возможности оценки риска суицида

Современное состояние молекулярно-генетических исследований в суицидологии и новые возможности оценки риска суицида

Автор: Розанов В.А., Кибитов А.О., Гайнетдинов Р.Р., Меринов А.В., Зотов П.Б.

Журнал: Суицидология @suicidology

Статья в выпуске: 1 (34) т.10, 2019 года.

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Обзор посвящен современному состоянию проблемы изучения генетических факторов суицидального поведения. Обсуждаются ключевые факты и закономерности, выявленные в ходе изучения наследуемости суицидального поведения с применением различных подходов, в частности, классической поведенческой генетики, стратегии генов-кандидатов и стратегии полногеномного сканирования, которая в последние годы приобретает все большее значение. Отдельно обсуждаются такие вопросы, как поиск доказательств изменений активности генов на уровне транскрипции, выявления эпигенетических феноменов и накопления белковых продуктов в аутопсийном материале, а также поиск информативных биомаркеров в крови. В генетике суицидального поведения прослеживается та же тенденция, которая в последнее время выявлена в отношении ряда психических расстройств - «исчезновение наследуемости» при переходе от классических психогенетических моделей (близнецовые исследования) к оценкам наследуемости на основе выявляемых мононуклеотидных маркеров, а также высокая степень взаимного перекрывания между маркерами расстройств (особенно депрессии и биполярного расстройства) и суицидального поведения...

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Самоубийство, суицидальное поведение, генетические факторы, поведенческая генетика, взаимодействие генов и среды, молекулярно-генетические маркеры, гены-кандидаты, эпигенетические феномены, продукты генной активности, головной мозг, биомаркеры крови

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Короткий адрес: https://sciup.org/140242191

IDR: 140242191   |   DOI: 10.32878/suiciderus.19-10-01(34)-3-20

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