State control of the vascular wall to antiaggregative by neutrophils in patients arterial hypertension with dyslipidemia patients treated with simvastatin
Автор: Medvedev I.N., Skorjatina I.A.
Рубрика: Оригинальные статьи
Статья в выпуске: 1, 2013 года.
Objective: set the activity limits the impact of vascular walls by aggregation ability of neutrophils in patients arterial hypertension with dyslipidemia patients. Material and methods. Under supervision were 34 sick arterial hypertension of 1-2 degrees with dyslipidemia II b type, risk 4, middle age. The control group was made by 26 healthy people of similar age. For the purpose of correction dyslipidemia all patients received a preparation simvastatin 10 mg for the night against appointment enalapril 10 mg two times a day. Results. In the conditions of an arterial hypertension with dyslipidemia decrease in control of a vascular wall over aggregative ability of neutrophils in many respects owing to infringements in lipidic an exchange, activation lipid peroxidation of plasma, easing of generation NO and formation prostacyclin is revealed. As a result of application simvastatin at sick the arterial hypertension with dyslipidemia notes improvement lipidic structure and processes lipid peroxidation in plasma and neutrophils, being accompanied by positive dynamics aggregative abilities of the last at the expense of optimization glycoprotein structure of their receptors. Conclusion. Use simvastatin hypertensive patients with dyslipidemia within 104 weeks can improve control of the vascular wall of platelet activity of neutrophils.
Neutrophils, vascular wall, arterial hypertension, dyslipidemia, simvastatin
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