Роль стволовых опухолевых клеток в канцерогенезе рака яичников

Автор: Генинг Снежанна Олеговна, Антонеева Инна Ивановна

Журнал: Ульяновский медико-биологический журнал @medbio-ulsu

Рубрика: Клиническая медицина

Статья в выпуске: 3, 2020 года.

Бесплатный доступ

Рак яичников (РЯ) - агрессивная злокачественная опухоль (ЗО) с рецидивирующим течением и низкой 5-летней выживаемостью пациенток. Большинство случаев диагностируется на распространенных стадиях, а терапевтические опции при РЯ ограничены, поэтому развитие первичной или вторичной резистентности к стандартной химиотерапии часто является фатальным для больной. Гетерогенность ЗО приводит к тому, что в ходе селекции выживают наиболее адаптированные клетки; для дальнейшей экспансии выжившего клона и закрепления устойчивого фенотипа в очаге им необходима высокая туморогенность. Стволовые опухолевые клетки (СОК) сочетают в себе эти характеристики и стоят на вершине иерархической структуры опухоли. Их биологические свойства, такие как способность к самообновлению, мультилинейная дифференцировка, схожи со свойствами нормальных стволовых клеток человека. Пластичность фенотипа и взаимодействие с иными составляющими паренхимы, стромы опухоли, а также внеопухолевыми элементами позволяют СОК противостоять неблагоприятным условиям: воздействию химиопрепаратов, иммунологическому надзору, физическим повреждающим факторам и аноикису в кровеносном и лимфатическом русле, непривычному микроокружению таргетных органов при отдаленном метастазировании. Все больше работ посвящается поиску путей использования СОК как предиктивного и прогностического биомаркера и как мишени для терапии, однако их однозначная идентификация, подсчет и специфическая элиминация представляют сложную проблему. В настоящее время наука находится на этапе накопления данных по этой тематике. В обзоре суммированы современные достижения в понимании биологии СОК и их влияния на клиническое течение РЯ. Поиск литературы осуществлялся по базам данных PubMed, Google Scholar, eLibrary.

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Рак яичников, стволовые опухолевые клетки, химиотерапия, канцерогенез, лекарственная устойчивость

Короткий адрес: https://readera.org/14117587

IDR: 14117587   |   DOI: 10.34014/2227-1848-2020-3-82-103

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