Роль генома в суицидальном поведении (обзор литературы)

Роль генома в суицидальном поведении (обзор литературы)

Автор: Козлов Вадим Авенирович, Голенков Андрей Васильевич, Сапожников Сергей Павлович

Журнал: Суицидология @suicidology

Статья в выпуске: 1 (42) т.12, 2021 года.

Бесплатный доступ

Обзор литературы посвящён анализу связи суицидального поведения как с генными локусами, так и установленными полиморфизмами генов. Рассмотрена связь с суицидами как отдельных генов, так и их групп. Особенно ценными являются сведения об однонуклеотидных полиморфизмах генов, регулирующих концентрацию кортизола (гены FKBP5, SLC6A3, CRHR1, CRHR2, SKA2), поскольку именно эта группа генов регулирует стресс-реакцию и участвует в формировании депрессивного состояния наряду с серотонин- (гены 5-HTTLPR, HTR2A) и адренергической (гены ADRA2A, ADRA2B) системами, патологию которых обычно связывают с разными формами депрессии и суицидами. Большой интерес представляют сведения, что разные полиморфизмы генов (CRHR1, CRHR2, SKA2), регулирующих концентрацию кортизола, характерны для половозрастных групп и потому определяют различия по частоте, возрасту и причинам совершения суицида. Кроме того, рассмотрена роль в реализации суицида полиморфизмов гена белков семейства YWHAE, гена нейротрофического фактора NTRK2, reward системы. Обсуждены вопросы формирования возможных путей поиска средств профилактики развития суицидального фенотипа. Авторами предложено выделить суицидальный фенотип в самостоятельную группу состояний, рассматриваемую как мультифакториальное заболевание, финальным итогом которого является совершение суицида или его попытка, требующее кодификации и нуждающееся в разработке классификации вариантов этиологии и патогенеза

Еще

Суицид, суицидальный фенотип, генная сеть, кортизол, адреналовая система, серотониновая система

Короткий адрес: https://sciup.org/140257622

IDR: 140257622   |   DOI: 10.32878/suiciderus.21-12-01(42)-3-22

Список литературы Роль генома в суицидальном поведении (обзор литературы)

  • Tsuang M.T. Risk of suicide in the relatives of schizophrenics, manics, depressives, and controls. J. Clin. Psychiatry. 1983; 44 (11): 396-400.
  • Zaheera J., Olfson M., Mallia E., et al. Predictors of suicide at time of diagnosis in schizophrenia spectrum disorder: A 20-year total population study in Ontario, Canada. Schizophrenia Research. 2020; 222: 382-388. DOI: 10.1016/j.schres.2020.04.025
  • Дмитриева Т.Б., Положий Б.С. Социальные и клинические проблемы суицидологии в системе мер по снижению преждевременной смертности и увеличению продолжительности жизни населения. Вестник Российской Академии медицинских наук. 2006; 8: 18-22. [Dmitrieva T.B., Polozhii B.S. Social and clinical problems of suicidology in the system of measures to reduce premature mortality and increase life expectancy of the population. Bulletin of the Russian Academy of Medical Sciences 2006; 8: 18-22.] (In Russ)
  • Шульга А.И., Сонник Г.Т. О суицидальных действиях психически больных. Журнал невропатологии и психиатрии им. С.С. Корсакова. 1986; 8: 1216-1217. [Shul'ga A.I., Sonnik G.T About suicidal actions of the mentally ill. Journal of Neuropathology and Psychiatry named after S. S. Korsakov. 1986; 8: 1216-1217.] (In Russ)
  • Goldney R.D. Suicide Prevention. Oxford University Press, 2008.
  • Grollman E.A. Suicide Prevention, Intervention, Postvention. 2nd ed. Beacon: Hill Press, 1988.
  • Смулевич А. Б. Депрессии при соматических и психических заболеваниях. М: МИА. 2007; 191-204. [Smulevich A.B. Depression in somatic and mental diseases. Moscow: MIА. 2007; 191-204.] (In Russ)
  • Rotenstein L.S., Ramos M.A., Torre M., et al. Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis. JAMA. 2016; 316 (21): 2214-2236. DOI: 10.1001/jama.2016.17324
  • McGirr A., Alda M., Séguin M. et al. Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder. Am. J. Psychiatry. 2009; 166 (10): 1124-1134. DOI: 10.1176/appi.ajp.2009.08111744
  • Roy A., Segal N.L., Centerwall B.S. et al. Suicide in twins. Arch. Gen. Psychiatry. 1991; 48 (1): 29-32. DOI: 10.1001/archpsyc.1991.01810250031003
  • Voracek M., Loib L.M. Genetics of suicide: a systematic review of twin studies. Wien Klin. Wochenschr. 2007; 119 (15-16): 463-475. DOI: 10.1007/s00508-007-0823-2
  • Докинз Р. Расширенный фенотип: длинная рука гена. Москва: Астрель, 2011; 512 с. [Dawkins R. Extended phenotype: the long arm of the gene. Moscow: Astrel, 2011; 512 p.] (In Russ)
  • Дюркгейм Э. Самоубийство: Социологический этюд / Пер. с фр. с сокр.; Под ред. В.А. Базарова. М.: Мысль, 1994; 399 с. [Durkheim E. Suicide: Sotsiologicheskiy etude / Per. s fr. s sokr.; Ed. V.A. Bazarov. Moscow: Mysl, 1994; 399 p.] (In Russ)
  • Heeringen C.V., Marusic A. Understanding of suicidal brain. Br. J. Psychiatry. 2003; 183 (4): 282-284. DOI: 10.1192/bjp.183.4.282
  • Roy B., Dwivedi Y. Understanding epigenetic architecture of suicide neurobiology: A critical perspective. Neurosci. Biobehav. Rev. 2017; 72: 10-27. DOI: 10.1016/j.neubiorev.2016.10.031
  • Zhang X., Yang H., Yu J., et al. Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene. Gene. 2002; 288: 9-18.
  • Pearson H. Genetics: what is a gene? Nature. 2006; 441 (7092): 398-401.
  • Gerstein M.B., Bruce C., Rozowsky J.S., et al. What is a gene, post-ENCODE? History and updated definition. Genome Research. 2007; 17: 669-681.
  • Ijdo J.W., Baldini A., Ward D.C. et al. Genetics Origin of human chromosome 2: An ancestral telomere-telomere fusion. Proc. Nadl. Acad. Sci. USA. 1991; 88: 9051-9055.
  • Human chromosome 2 map view. Vertebrate Genome Annotation (VEGA) database. The Wellcome Trust Sanger Institute. https://vega.archive.ensembl.org/Homo_sapiens/Location/Chromosome?chr=2;r=2:1-242193529
  • Hesselbrock V., Dick D., Hesselbrock M. et al. The search for genetic risk factors associated with suicidal behavior. Jr. Alcohol. Clin. Exp. Res. 2004; 5 (Suppl.): 70S-76S. DOI: 10.1097/01.alc.0000127416.92128.b0
  • Zubenko G.S., Maher B.S., Hughes H.B. 3rd et al. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2004; 129B (1): 47-54. DOI: 10.1002/ajmg.b.30092
  • Butler A.W., Breen G., Tozzi F., et al. A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2010; 153 B (8): 1465-1473. DOI: 10.1002/ajmg.b.31127
  • Docherty A.R., Shabalin A.A., DiBlasi E. et al. Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents. Psychiatry. 2020; 177 (10): 917-927. DOI: 10.1176/appi.ajp.2020.19101025
  • Ichimura T., Isobe T., Okuyama T. et al. Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase dependent activator of tyrosine and tryptophan hydroxylases. Proc. Natl. Acad. Sci. USA. 1988; 85 (19): 7084-7088. DOI: 10.1073/pnas.85.19.7084
  • 26.https://omim.org/entry/605066?search=ywhae%20gene&highlight=gene%20 ywhae
  • Халилова З.Л., Зайнуллина А.Г., Валиуллина А.Р. и др. Анализ ассоциаций полиморфных локусов гена YWHAE с суицидальным поведением. Генетика. 2013; 49 (6): 767-772. [Khalilova Z.L., Zainullina A.G., Valiullina A.R., et al. Analysis of associations of polymorphic loci of the YWHAE gene with suicidal behavior. Genetics. 2013; 49 (6): 767-772/] (In Russ)
  • Yanagi M., Shirakawa O., Kitamura N.? et al. Association of 14-3-3 gene haplotype with completed suicide in Japanese. J. Hum. Genet. 2005; 50(4): 210-216. DOI: 10.1007/s10038-005-0241-0
  • Liu J., Zhang H.X., Li Z.Q et al. The YWHAE gene confers risk to major depressive disorder in the male group of Chinese Han population. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2017; 77: 172-177. DOI: 10.1016/j.pnpbp.2017.04.013
  • Middleton F., Peng L., Lewis D., et al. Altered expression of 14- 3-3 genes in the prefrontal cortex of subjects with schizophrenia. Neuropsychopharmacology. 2005; 30 (5): 974-983. DOI: 10.1038/sj.npp.1300674
  • Jia Y., Yu X., Zhang B. et al. An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3- monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population. Eur. Psychiatry. 2004; 19 (6): 377-379. DOI: 10.1016/j.eurpsy.2004.07.006
  • Kohli M.A., Salyakina D., Pfennig A., et al. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Arch. Gen. Psychiatry. 2010; 67(4): 348-359. DOI: 10.1001/archgenpsychiatry.2009.201
  • Hennings J.M., Kohli M.A., Czamara D., et al. Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach. PLoS One. 2013; 8 (6): e64947. DOI: 10.1371/journal.pone.0064947
  • Sekiguchi H., Iritani S., Habuchi C., et al. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia. Brain Res. 2011; 1392: 47-53. DOI: 10.1016/j.brainres.2011.03.058
  • Toyooka K., Shionoya A., Gambello M., et al. 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat. Genet. 2003; 34: 274-285. DOI: 10.1038/ng1169
  • Božina N., Jovanović N., Podlesek A., et al. Suicide ideators and attempters with schizophrenia – the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants. J. Psychiatr. Res. 2012; 46 (6): 767-773. DOI: 10.1016/j.jpsychires.2012.03.008
  • Fukutake M., Hishimoto A., Nishiguchi N. et al. Association of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2008; 32 (6): 1428-1433. DOI: 10.1016/j.pnpbp.2008.02.003
  • Escribá P.V., Ozaita A., García-Sevilla J.A. Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. Neuropsychopharmacology. 2004; 29 (8): 1512-1521. DOI: 10.1038/sj.npp.1300459
  • Molnar S., Mihanović M., Grah M., et al. Comparative study on gene tags of the neurotransmission system in schizophrenic and suicidal subjects. Coll. Antropol. 2010; 34 (4): 1427-1432.
  • Giegling I., Hartmann A.M., Möller H.J., et al. Anger- and aggression- related traits are associated with polymorphisms in the 5-HT-2A gene. J. Affective Disorders. 2006; 96 (1-2): 75-81. DOI: 10.1016/j.jad.2006.05.016
  • Karanović J., Šviković S., Pantović M., et al. Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders. World J. Biol. Psychiatry. 2015; 16 (4): 261-271. DOI: 10.3109/15622975.2014.1000374
  • Wannemueller A., Forkmann T., Glaesmer H., et al. The role of the 5-HTTLPR polymorphism in acquired capability for suicide. Suicide Life Threat Behav. 2020; 50 (6): 1121-1126. DOI: 10.1111/sltb.12660
  • Bokor J., Krause S., Torok D., et al. "Out, out, brief candle! Life's but a walking shadow": 5-HTTLPR is associated with current suicidal ideation but not with previous suicide attempts and interacts with recent relationship problems. Front. Psychiatry. 2020; 11: 567. doi: 10.3389/fpsyt.2020.00567.
  • Sanabrais-Jiménez M.A., Sotelo-Ramirez C.E., Ordoñez- Martinez B., et al. Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt. J. Neural. Transm. (Vienna). 2019; 126 (5): 637-644. DOI: 10.1007/s00702-019-01991-4
  • Ludwig B., Kienesberger K., Carlberg L., et al. Influence of CRHR1 Polymorphisms and Childhood Abuse on Suicide Attempts in Affective Disorders: A GxE Approach. Front Psychiatry. 2018; 9: 165. DOI: 10.3389/fpsyt.2018.00165
  • Ben-Efraim Y.J., Wasserman D., Wasserman J., et al. Geneenvironment interactions between CRHR1 variants and physical assault in suicide attempts. Genes Brain Behav. 2011; 10 (6): 663-672. DOI: 10.1111/j.1601-183X.2011.00703.x
  • Wasserman D., Sokolowski M., Rozanov V., et al. The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress. Genes Brain Behav. 2008; 7 (1): 14-19. DOI: 10.1111/j.1601-183X.2007.00310.x
  • Papiol S., Arias B., Gastó C., et al. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J. Affect Disord. 2007; 104 (1-3): 83-90. DOI: 10.1016/j.jad.2007.02.017.
  • Höfer P., Schosser A., Calati R., et al. The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment – a European multicentre study. Int. Clin. Psychopharmacol. 2016; 31 (1): 1-7. DOI: 10.1097/YIC.0000000000000101
  • Wang J.Y., Jia C.X., Lian Y., et al. Association of the HTR2A 102T/C polymorphism with attempted suicide: a meta-analysis. Psychiatr. Genet. 2015; 25 (4): 168-177. DOI: 10.1097/YPG.0000000000000091
  • Attwood B.K., Bourgognon J.-M., Patel S., et al. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature. 2011; 473 (7347): 372-375. DOI: 10.1038/nature09938
  • Supriyanto I., Sasada T., Fukutake M., et al. Association of FKBP5 gene haplotypes with completed suicide in the Japanese population. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2011; 35 (1): 252-256. DOI: 10.1016/j.pnpbp.2010.11.019
  • Hernández-Díaz Y., González-Castro T.B., Tovilla-Zárate C.A., et al. Association between polymorphisms of FKBP5 gene and suicide attempt in a Mexican population: A case-control study. Brain Res. Bull. 2021; 166: 37-43. DOI: 10.1016/j.brainresbull.2020.11.002
  • Roy A., Gorodetsky E., Yuan Q., et al. Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology. 2010; 35 (8): 1674-1683. DOI: 10.1038/npp.2009.236
  • Kaminsky Z., Wilcox H.C., Eaton W.W. et al. Epigenetic and genetic variation at SKA2 predict suicidal behavior and posttraumatic stress disorder. Transl. Psychiatry. 2015; 5 (8): e627. DOI: 10.1038/tp.2015.105
  • Pandey G.N., Rizavi H.S., Zhang H., et al. The expression of the suicide-associated gene SKA2 Is decreased in the prefrontal cortex of suicide victims but not of nonsuicidal patients. Int. J. Neuropsychopharmacol. 2016; 19 (8): pyw015. DOI: 10.1093/ijnp/pyw015
  • Xie M., Bu Y. SKA2/FAM33A: A novel gene implicated in cell cycle, tumorigenesis, and psychiatric disorders. Genes Dis. 2018; 6 (1): 25-30. DOI: 10.1016/j.gendis.2018.11.001
  • Sadeh N., Spielberg J.M., Logue M.W., et al. SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans. Mol. Psychiatry. 2016; 21 (3): 357-363. DOI: 10.1038/mp.2015.134
  • Lutz P.E., Zhou Y., Labbe A., et al. Decreased expression of nociception / orphanin FQ in the dorsal anterior cingulate cortex of suicides. Eur. Neuropsychopharmacol. 2015; 25 (11): 2008- 2014. DOI: 10.1016/j.euroneuro.2015.08.015
  • Brundin L., Björkqvist M., Petersén A., et al. Eur. Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder. Neuropsychopharmacol. 2007; 17 (9): 573-579. DOI: 10.1016/j.euroneuro.2007.01.005
  • Hurd Y.L., Herman M.M., Hyde T.M., et al. Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects. Mol. Psychiatry. 1997; 2 (6): 495-500. DOI: 10.1038/sj.mp.4000319
  • Gross-Isseroff R., Dillon K.A., Israeli M., et al. Regionally selective increases in mu opioid receptor density in the brains of suicide victims. Brain Res. 2010; 530 (2): 312-316. DOI: 10.1016/0006-8993(90)91301-v
  • Gabilondo A.M., Meana J.J., García-Sevilla J.A. Increased density of mu-opioid receptors in the postmortem brain of suicide victims. Brain Res. 1995; 682 (1-2): 245-250. DOI: 10.1016/0006-8993(95)00333-l
  • Dachet F., Brown J.B., Valyi-Nagy T., et al. Selective timedependent changes in activity and cell-specific gene expression in human postmortem brain. Sci Rep. 2021; 11: 6078. DOI: 10.1038/s41598-021-85801-6
  • Noble P.A., Pozhitkov A.E. Cryptic sequence features in the active postmortem transcriptome. BMC. Genomics. 2018; 19 (675): DOI: 10.1186/s12864-018-5042-x
  • Furczyk K., Schutová B., Michel T., et al. The neurobiology of suicide – a review of post-mortem studies. J. Mol. Psychiatry. 2013; 1 (1): 2. DOI: 10.1186/2049-9256-1-2
  • Cobley J.N., Fiorello M.L., Bailey D.M. 13 reasons why the brain is susceptible to oxidative stress. Redox Biol. 2018; 15: 490-503. DOI: 10.1016/j.redox.2018.01.008
  • Turecki G. The molecular bases of the suicidal brain. Nat. Rev. Neurosci. 2014; 15 (12): 802-816. DOI: 10.1038/nrn3839
  • Mirkovic B., Laurent C., Podlipski M.-A., et al. Genetic association studies of suicidal behavior: a review of the past 10 years, progress, limitations, and future directions. Front Psychiatry. 2016; 7: 158. DOI: 10.3389/fpsyt.2016.00158
  • Mann J.J., Currier D.M. Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression. Eur. Psychiatry. 2010; 25 (5): 268-271. DOI: 10.1016/j.eurpsy.2010.01.009
  • Руженков В.А., Руженкова В.В., Боева А.В. Концепции суицидального поведения. Суицидология. 2012; 4: 52-60. [Ruzhenkov V.A., Ruzhenkova V.V., Boeva A.V. Concepts of suicidal behavior. Suiсidology. 2012; 4: 52-60.] (In Russ)
  • Хритинин Д.Ф., Есин А.В., Сумарокова М.А., Щукина Е.П. Основные модели суицидального поведения. Сибирский вестник психиатрии и наркологии. 2017; 3 (96): 71-77. [Khritinin D.F., Esin A.V., Sumarokova M.A., Shchukina E.P. Basic models of suicidal behavior. Siberian Bulletin of Psychiatry and Narcology. 2017; 3 (96): 71-77.] DOI: 10.26617/1810-31112017-3(96)-71-77. (In Russ)
  • Ludwig B., Roy B., Wang Q. et al. The life span model of suicide and its neurobiological foundation. Front Neurosci. 2017; 11: 74. DOI: 10.26617/1810-3111-2017-3(96)-71-77.: 10.3389/fnins.2017.00074
  • Розанов В.А. Гены и суицидальное поведение. Суицидология. 2013; 4 (1): 3-14. [Rozanov V.A. Genes and suicidal behavior. Suicidology. 2013; 4 (1): 3-14.] (In Russ)
  • Guner N., Kulikova Y., Llull J. Marriage and Health: Selection, Protection, and Assortative Mating. Eur. Econ. Rev. 2018; 104: 138-166. DOI: 10.1016/j.euroecorev.2018.02.005
  • Розанов В.А., Кибитов А.О., Гайнетдинов Р.Р. и др. Современное состояние молекулярно-генетических исследований в суицидологии и новые возможности оценки риска суицида. Суицидология. 2019; 10 (1): 3-20. [Rozanov V.A., Kibitov A.O., Gainetdinov R.R. et al. The current state of molecular genetic research in suicidology and new opportunities for assessing the risk of suicide. Suicidology. 2019; 10 (1): 3-20.] DOI: 10.32878/suiciderus.19-10-01(34)-3-20 (In Russ / Engl)
Еще
Статья научная
SciUp 2024 © 2024 ©