“Silent” ACTH-secreting carcinoma of hypophysis with extra-and intracranial metastases: case report and literature review

The article presents a clinical case of “silent” ACTH-secreting pituitary carcinoma with multiple extra- and intracranial metastases. The patient received combined treatment including transsphenoidal removal of the tumor, 18 courses of palliative chemotherapy, 3 courses of stereotactic irradiation for primary tumor, therapy with cabergoline and somatostatin analogues. The patient lived 2 years and 9 months after the primary diagnosis of the tumor was made. There was a decrease in size of the primary tumor after radiotherapy, and chemotherapy resulted in a decrease in the metabolic activity of metastases which increased the life expectancy of the patient.