Neuroimmunoendocrine dysfunctions in mental disorders and addictions

The study of pathogenetic mechanisms of mental disorders and addictions with use of complex clinical-biological approach is one of the tasks of basic research within scientific platform ‘Psychiatry and addictions”. Objective: to investigate participation of the immune and endocrine systems in clinical-dynamic mechanisms of mental disorders and addictions. Material and Methods: A complex clinical-immunoendocrine examination of 149 patients with non-psychotic mental disorders, 65 schizophrenic patients, 136 patients with drug addiction and 18 males with alcohol dependence is carried out. The phenotyping of immunocompetent cells according to clusters of differentiation by method of flow cytometry, identification of concentrations of serum immunoglobulins of classes M, G, and A and the level of hormones by the method of IEA; identification of concentration of cytokines on multiplex analyzer MAGPIX according to Luminex xMAP Technology (USA); identification of phagocytic activity of neutrophils in the test with melamine - formaldehyde latex is performed. Results: Data are obtained that give evidence of participation of the immu-noendocrine system in the formation of psychopathological disorders and their polymorphism in non-psychotic mental disorders with dominance of anxiety and depressive symptoms. Based on immunological approach methods of prediction of protracted course of neurotic, stress-related and somatoform disorders are developed. Deviations in the system of neuroimmunoendocrine regulation are a common pathogenetic mechanism of development of endogenous disorders. Data on features of action of the atypical neuroleptic risperidone in the process of the therapy in the main parameters of the immunity of schizophrenic patients respective from presence or absence of medicinal hyperprolactinemia are obtained. Deregulation of parameters of the immunoendocrine system in addictions is established at all studied stages of withdrawal syndrome that gives evidence of instability of achieved therapeutic remission, necessity of carrying out the further rehabilitative activities, development of approaches to new algorithms of treatment and rehabilitation of patients for the purpose of stabilization of remissions and prevention of early relapses.