Negative aspects of the comorbid course of COPD and CHF

Автор: Kravchenko A.Ya., Tokmachev R.E., Chernik T.A.

Журнал: Международный журнал гуманитарных и естественных наук @intjournal

Статья в выпуске: 7-3 (70), 2022 года.

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The paper focuses on challenges in the diagnosis and treatment choice for patients with CHF and COPD. It is underlined that in the pathogenesis of both diseases there are common processes of systemic inflammation, oxidative stress, and endothelial dysfunction. One of the main systemic inflammation markers is highly sensitive C-reactive protein (hs-CRP). The fact that N-terminal pro-brain natriuretic peptide (NT-proBNP) is a standard laboratory biomarker of CHF, but the adverse effect of COPD on the cardiovascular system can also affect its level in blood serum is also stressed. The study was aimed to assess the impact of COPD on the level of NT-proBNP, hs-CRP and the functional status of patients with CHF. The results obtained demonstrate that combination of COPD and CHF amplifies systemic inflammation and myocardial remodeling processes determined by the level of NT-proBNP. A negative effect of COPD on the functional status of patients with CHF with different left ventricular ejection fraction was reported. The results obtained contribute to expansion of the diagnostic capabilities, and prognosis and effectiveness of pharmacotherapy in patients with COPD and CHF.


Chf, copd

Короткий адрес:

IDR: 170194998   |   DOI: 10.24412/2500-1000-2022-7-3-22-26

Список литературы Negative aspects of the comorbid course of COPD and CHF

  • Díez-Villanueva P, Alfonso F. Heart failure in elderly // J Geriatr Cardiol. 2016. V. 13. № 2. P. 115-117.
  • EURObservationalResearch Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot) / Maggioni A, Dahlström U, Filippatos G, et al. // Eur J Heart Fail. 2013;15(7):808-17.
  • An impact of cardiovascular comorbidity on course and prognosis of chronic obstructive pulmonary disease / Gaynitdinova V.V., Avdeev S.N., Neklyudova G.V., et al. // Pulmonologiya. 2019; 29(1): 35-42. (In Russ.).
  • Tokmachev R.E., Budnevsky A.V., Kravchenko A.Ya. The role of inflammation in the pathogenesis of chronic heart failure // Therapeutic archive. 2016; 88 (9): 106-110.
  • Use of walking tests in pulmonology / Ots O.N., Maliev B.M., Chushkin M.I., et al. // Therapeutic archive. 2012; 84 (3): 62-67. (In Russ.).
  • Prognostic Role of NT-proBNP for in-Hospital and 1-Year Mortality in Patients with Acute Exacerbations of COPD / Li H, Zeng Z, Cheng J, et al. // Int J Chron Obstruct Pulmon Dis. 2020; 8(15): 57-67.
  • De Miguel DJ, Morgan JC, Jimenez Garcia R. The association between COPD and heart failure risk: a review // Int J Chron Obstruct Pulmon Dis. 2013; 8: 305-312.
  • Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease / Thomsen M, Dahl M, Lange P, et al. // Am. J. Respir. Crit. Care Med. 2012; 186: 982-988.
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