Critical analysis of the mechanostat theory. Clinical-and-pathogenetic aspects of reorganizing architecture of skeleton at different stages of its development

The role of genetic and non-genetic factors in the process of skeleton growth, maturation and involution considered from clinical-and-pathogenetic positions. Two main paradigms of skeletal architecture development and formation analyzed according to the mechanical demands emerging during performing locomotor functions. According to the first one, genetic factors are dominating (C.O. Lovejoy et al.). And according to the other (H. Frost), genetics creates only the initial conditions. One of the most important biological problems to be solved by the organism during realization of the genetic program of its growth and maturation, as demonstrated, is achieving the maximally possible (under specific conditions) skeletal mass with the architecture providing the highest level of strength reserve in every point of the skeleton.