Clinical-dynamic and clinical-social factors in akathisia in patients with schizophrenia, receiving antipsychotic therapy

Akathisia is a neuropsychiatrie syndrome that is developing as a result of antipsychotic treatment and negatively affects the course of schizophrenia and clinical and social indicators. Objective: to investigate prevalence of akathisia in patients with schizophrenia receiving antipsychotic therapy, with the assessment of clinical dynamics and clinical-social factors that contribute. 198 patients with schizophrenia, aged from 18 to 65 years who were treated in psychiatric hospitals of Tomsk and Kemerovo, with the use of the Positive and Negative Syndrome Scale (PANSS), Barnes Akathisia Rating Scale (BARS, BAS), the Social Adaptation Self-Evaluation Scale (SSAS), as well as using a basic map of formalized sociodemographic and clinical-dynamic features developed at the Mental Health Research Institute (Tomsk). The reliability of the statistical differences was estimated using the twosided Fisher, test Mann-Whitney U test and Chi-squared. The incidence of akathisia in patients with schizophrenia was 36%. Considering the main factors, statistically significant influence of such factors as duration of the disease, negative symptoms and smoking was found. These data are required to select a personalized antipsychotic therapy to reduce the risk of the development of akathisia in patients with schizophrenia.