Interleukin-6 and diabetic nephropathy: pathogenic interconnections, targets for nephroprotection

Автор: Pchelin I.Y., Bayrasheva V.K., Shishkin A.N., Vasilkova O.N., Hudiakova N.V.

Журнал: Juvenis scientia @jscientia

Рубрика: Медицинские науки

Статья в выпуске: 12, 2017 года.

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The article summarizes recent data on the role of interleukin-6 (IL-6) in the development of diabetic nephropathy (DN) and related pathological conditions. The effects determined by the activation of membrane (IL-6R) and soluble (sIL-6R) receptors are described. Clinical and experimental studies of the IL-6 interconnections with obesity, insulin resistance, renal fibrosis, cardiomyopathy and anemia are analyzed. The strategies of anti-inflammatory therapy and nephroprotection are discussed.

Interleukin-6, diabetes mellitus, insulin, insulin resistance, chronic kidney disease, diabetic nephropathy, tocilizumab, adam-10, adam-17

Короткий адрес: https://sciup.org/14110446

IDR: 14110446

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