Pharmacotherapy of depression: a comprehensive clinical approach

Objective of study: to study the influence of clinical and chronobiological characteristics of patients on the severity of depression and specifics of psychopharmacotherapy. Materials: A clinical-psychopathological study of 100 patients with depression in 2014-2017 was carried out, of them 68 women and 32 men aged from 18 to 77 years (mean age 48±16 years). Methods: clinical-psychopathological, psychometric (MADRS, HDRS-21, PSQI, SPAQ, MEQ, TAT, IM), statistical. Results: In the article the results of study of the influence of clinical and chronobiological characteristics on the specifics of psychopharmacotherapy of patients with the verified diagnosis of depression (F31.3-F31.5, F32, F33 according to criteria of ICD-10) were described. Conclusion. With the use of mathematical methods of statistical analysis the informative clinical and chronobiological factors were identified, which influenced on the severity of the state of the patient after 8 weeks of the therapy: age to the moment of seeking for help, the chronotype, the clinical syndrome, initial severity of the state. Individual biorhythmological status of the patient can influence the efficiency of psychopharmacotherapy. Taking into account the findings can contribute to the improvement in the quality of the medical aid of this category of patients.