COVID-19: известные препараты, новые возможности

Автор: Аширметов А.Х., Мавлянов И.Р., Мавлянов З.И., Жарылкасынова Г.Ж.

Журнал: Анализ риска здоровью @journal-fcrisk

Рубрика: Аналитические обзоры

Статья в выпуске: 4 (32), 2020 года.

Бесплатный доступ

К настоящему времени коронавирусная болезнь, вызывающая острый респираторный синдром, выявлена почти во всех странах. Глобальное распространение вируса (SARS-CoV-2) стало пандемией, и не существует эффективной и утвержденной терапии против COVID-19. Ввиду чрезвычайной ситуации большинство потенциальных лекарственных средств для лечения COVID-19 допускаются к использованию пока на основании информации о безопасности и эффективности против SARS-CoV. Сейчас только лопинавир / ритонавир и ремдесивир являются единственными противовирусными препаратами, включенными в серьезные менеджмент-протоколы лечения COVID-19, а приемлемой альтернативой, возможно, является комбинированная терапия гидроксихлорохином с азитромицином. В сложившейся ситуации в качестве возможных методов лечения COVID-19 с учетом имеющихся знаний о патофизиологии инфекции стали предлагаться многие лекарственные вещества, обычно используемые в терапии других заболеваний. На основании известной в настоящее время информации в области путей вхождения в клетки вируса SARS-CoV-2, патофизиологических аспектов развития «цитокинового шторма» осуществлен обзор использования при COVID-19 противовирусных препаратов, противовоспалительных и иммуносупрессивных средств, витаминов и микроэлементов, которые сейчас широко применяются для лечения и профилактики различных заболеваний. Большинство испытуемых лекарственных средств, а также препараты цинка, витамины С и D3 обладали, наряду с иммуномодулирующим, еще и противовоспалительными свойствами или блокировали пути вхождения в клетки, или нарушали процесс внутриклеточной репликации вируса SARS-CoV. Извлекая уроки предыдущего опыта по преодолению SARS и MERS, в клинической практике для лечения COVID-19 использовалась серия существующих лекарств, а клинические испытания, оценивающие их эффективность и безопасность при COVID-19, продолжаются. Хотя предложено много видов лечения, для определения наиболее подходящих из них необходимо проводить специально спланированные рандомизированные клинические триалы, основанные на принципах доказательной медицины.

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Коронавирус, противовирусные препараты, иммуномодулирующие препараты, противовоспалительные препараты, лекарственные препараты, клинические испытания

Короткий адрес: https://readera.org/142226402

IDR: 142226402   |   DOI: 10.21668/health.risk/2020.4.19

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