Боль и воспаление. Часть 2. Анальгетический потенциал противовоспалительных препаратов

Боль и воспаление. Часть 2. Анальгетический потенциал противовоспалительных препаратов

Автор: Каратеев А.Е., Каратеев Д.Е., Давыдов О.С.

Журнал: Научно-практическая ревматология @journal-rsp

Рубрика: Прогресс в ревматологии в XXI веке

Статья в выпуске: 1 т.55, 2017 года.

Бесплатный доступ

Воспалительная реакция и развитие боли - взаимозависимые процессы. Воспаление, сопровождающееся гиперпродукцией провоспалительных цитокинов и медиаторов, не только вызывает боль, но и является основной причиной ее хронизации. Поэтому главным направлением анальгетической терапии следует считать использование противовоспалительных препаратов. Во второй части обзора обсуждается анальгетический потенциал различных фармакологических групп, обладающих противовоспалительным действием, - нестероидных противовоспалительных препаратов, глюкокортикоидов, генноинженерных биологических препаратов, метотрексата, медленно действующих противовоспалительных средств («хондропротекторов»), а также ряда перспективных и экспериментальных средств, таких как ингибиторы фактора роста нервов. Приводятся данные основных клинических исследований, в которых оценивалось обезболивающее действие этих препаратов при различных заболеваниях и патологических состояниях.

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Боль, воспаление, парацетамол, нестероидные противовоспалительные препараты, глюкокортикоиды, метотрексат, генно-инженерные биологические препараты, ингибиторы фактора роста нервов

Короткий адрес: https://sciup.org/14945796

IDR: 14945796   |   DOI: 10.14412/1995-4484-2017-58-67

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